Influence of ovariectomy and estradiol treatment on calcium homeostasis during aging in rats

Archives of Physiology and Biochemistry
N GaumetJ P Barlet

Abstract

Study was carried out an Wistar female rats to evaluate the consequences of ovariectomy and 17 beta-estradiol substitutive treatment during aging on bone. Ca metabolism and calciotropic hormones. Three groups of fifteen rats, mature, old and senescent (4-, 10-, and 28 month-old) female were fed a diet (6 g/100 g BW/day) containing 0.9% Ca and 0.8% Pi, Within each group, 10 rats were surgically ovariectomized (OVX). From day 1 until day 60 after OVX, they were subcutaneously injected with either 17 beta-estradiol (E: 10 micrograms/kg BW/48 h; n = 5) or with solvent alone (OVX; n = 5). Five other rats were sham operated (SH) and received solvent alone. Animals were put in balance 1 day per week to determine Ca and Pi intestinal apparent absorption and urinary pyridinium cross-links excretion was measured by HPLC. All rats were killed by exsanguination 60 days after OVX. Plasma was collected for measurement of intact parathyroid hormone (PTH), calcitonin (CT), insulin-like growth factor-1 (IGF-1), Ca and Pi. The success of OVX was confirmed at necropsy by observation of marked atrophy of the uterine horns. The right femur was collected, cleaned from adjacent tissue and used for mineral analysis. Despite correct matching for feedin...Continue Reading

References

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Citations

Dec 14, 2011·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·W QiN Liu
Feb 24, 2004·Journal of Medicinal Food·Min-Kyoung PaikAe-Son Om
Feb 22, 2002·Japanese Journal of Pharmacology·Masatoshi KobayashiYasuhiro Akiyama
May 11, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·D N Kalu, C Chen
Oct 31, 2015·Climacteric : the Journal of the International Menopause Society·Y XuN Lin
Jun 15, 2011·Journal of Ethnopharmacology·Rong ZhangQi-Bing Mei
May 3, 2014·Journal of Ethnopharmacology·Rong ZhangQi-Bing Mei
Nov 17, 2015·Experimental Animals·María M NendaPatricia M Mandalunis
Dec 12, 2001·American Journal of Physiology. Endocrinology and Metabolism·Lionel VerdierDominique Meynial-Denis
Feb 4, 2003·Journal of Pineal Research·Marta G LadizeskyDaniel P Cardinali
Feb 4, 2003·Journal of Pineal Research·Daniel P CardinaliCarlos Mautalen

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