PMID: 11323147Apr 27, 2001Paper

Influence of painful chronic neuropathy on neurogenic inflammation

Pain
Norifumi Yonehara, M Yoshimura

Abstract

The effect of topical application of capsaicin cream on neurogenic inflammation was investigated in a neuropathic pain model in rat. The neuropathic state was induced by loose ligation of the sciatic nerve with a chromic gut suture. A marked thermal hyperalgesia was observed in response to heat stimulation applied to the operated side from 3 days through 2 weeks, followed by a gradual return to the control level 35 days after surgery. In sham-operated animals, topical application of capsaicin cream to both sides of the hind paw, the instep and sole, as well as antidromic stimulation of the sciatic nerve led to a significant increase in the amounts of Evans blue and substance P (SP) released into the perfusates. This stimulus-induced extravasation was significantly suppressed by pretreatment with RP67580, an NK1 antagonist. On day 7 after ligation, capsaicin- and antidromic stimulation-induced extravasation were significantly reduced. At this time, both amount of SP released immediately after application of capsaicin and during antidromic stimulation were almost similar to that in sham-operated rats, whereas the basal amount of SP release significantly increased in ligated animals. In particular a major release of SP was detecte...Continue Reading

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Citations

Mar 29, 2003·Current Allergy and Asthma Reports·Chih-Feng Tai, James N Baraniuk
Dec 31, 2002·Chemistry and Physics of Lipids·T Philip MalanFrank Porreca
Jun 6, 2003·Progress in Neurobiology·Jana Sawynok, Xue Jun Liu
Aug 19, 2007·Nursing Management·Kathy A Cadden
Sep 18, 2015·Journal of Basic and Clinical Physiology and Pharmacology·Gurmanpreet KaurPuneet Kumar
Apr 17, 2009·Brain Research·Astrid Juhl TerkelsenTroels Staehelin Jensen
Jul 16, 2005·Bioorganic & Medicinal Chemistry Letters·Ho-Jane ShueGeoffrey B Varty
Jul 3, 2008·The Journal of the American Dental Association·Giuseppe Alessandro ScardinaPietro Messina
Jun 26, 2012·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Patrick L Stemkowski, Peter A Smith

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