PMID: 8719906Dec 1, 1995

Influence of partial hepatectomy in dogs on trimethadione metabolism and microsomal monooxygenases

Xenobiotica; the Fate of Foreign Compounds in Biological Systems
E TanakaT Horie


1. The recovery of trimethadione (TMO) metabolism and its association with liver weight and the activity of TMO N-demethylase have been reported in rat following partial (68%) hepatectomy. In the present study, we examined the effect of liver regeneration on hepatic P450 isozymes and TMO metabolism in dog. 2. The ratio of dimethadione (DMO), being the only TMO metabolite, to TMO at 2 h after i.v. injection of TMO (4 mg/kg) fell to 80% of that in the preoperative animals by 24 h after hepatectomy. The DMO/TMO ratio gradually recovered from days 7 to 14, and by day 21 after hepatectomy it had increased to about 25%. At 28 days post-hepatectomy the ratio had returned to preoperative levels. 3. The activity of benzphetamine N-demethylase, TMO N-demethylase, p-nitro-anisole O-demethylase and aniline hydroxylase increased 3 days post-hepatectomy, exhibiting levels 4.77, 3.45, 1.51 and 1.91 times greater respectively than that of the preoperative liver in the same animal. Two weeks post-hepatectomy these activities had returned to normal. The activity of the 16 beta- and 2 beta-hydroxylation of testosterone was unchanged. However, the activity of 6 beta-hydroxylase decreased 7 days post-hepatectomy, while 16 alpha-hydroxylation had in...Continue Reading


Feb 16, 1991·Biochimica Et Biophysica Acta·P J CiaccioJ R Halpert
Jan 1, 1987·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·A W SzawlowskiH Joyeux
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May 1, 1987·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J B GrossA Zimmermann
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Jun 1, 1984·The Australian Journal of Experimental Biology and Medical Science·G C Farrell, L Zaluzny
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Jul 31, 1980·Biochemical and Biophysical Research Communications·M PrestaG Ragnotti
Feb 1, 1993·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·E TanakaY Kuroiwa

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