PMID: 8970550Dec 1, 1996Paper

Influence of partial nerve injury in the rat on efferent function of sympathetic and antidromically acting sensory nerve fibers

The Journal of Trauma
H KurversM J Jacobs

Abstract

To investigate how partial injury of a large peripheral nerve affects efferent (vasomotor) function of sympathetic and antidromically acting sensory nerve fibers. Randomized animal study. We assessed, by laser Doppler flowmetry, skin blood flow (SBF) in the hindpaw of male Lewis rats before partial injury of the ipsilateral sciatic nerve (through loose ligation) as well as at an early stage (day 4) and at a later stage (day 21) after this procedure. This procedure has been reported to induce signs and symptoms like those observed in patients with causalgia. At the two time points after nerve injury, SBF was assessed before and after (chemical) blockade of sensory and nonsensory (sympathetic) sciatic nerve fibers. Furthermore, at day 21 we measured the density of sympathetic nerve fibers in footpad arteries. At day 4, compared with preligation values, we observed an increase in SBF that was reduced by blockade of sensory nerve fibers. Subsequent blockade of nonsensory nerve fibers further reduced SBF. At day 21, SBF was decreased compared with preligation values. Blockade of sensory nerve fibers further reduced SBF, and subsequent blockade of nonsensory nerve fibers did so as well. The density of sympathetic nerve fibers was low...Continue Reading

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Citations

Aug 19, 2008·The Journal of Surgical Research·Edward C T H TanR Jan A Goris
Nov 3, 2009·The Journal of Pain : Official Journal of the American Pain Society·Marissa de MosTerence J Coderre
Jan 19, 1999·Vascular Medicine·H A Kurvers
Jun 15, 2012·The Journal of Trauma and Acute Care Surgery·Wolfgang HappakLukas K Kriechbaumer
Dec 4, 2020·Physiological Reviews·Christian AalkjærJo G R De Mey

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