Influence of pegylated interferon-alpha therapy on plasma levels of citrulline and arginine in melanoma patients

Amino Acids
D FekkesG Stoter

Abstract

The aim of this study was to evaluate the effect of pegylated interferon-alpha (PEG-IFN-alpha) on the plasma citrulline/arginine ratio, regarded as an index of nitric oxide (NO) synthesis, in patients with high-risk melanoma. Forty patients were randomly assigned to either PEG-IFN-alpha treatment (n = 22) or to observation only (control group, n = 18). The treatment group received 6 microg PEG-IFN-alpha/kg once a week during 8 weeks, followed by a maintenance dose of 3 microg/kg/wk. Blood was collected at different time points, plasma concentrations of citrulline and arginine were measured and the ratio of citrulline/arginine was calculated. Patients treated with PEG-IFN-alpha showed a significant decrease in the concentrations of citrulline and in the citrulline/arginine ratio during the whole study period, both compared to baseline values and to the control group. The data suggest that therapy with PEG-IFN-alpha results in a marked decrease in the synthesis of NO in melanoma patients.

References

Sep 23, 1994·Cell·H H Schmidt, U Walter
Nov 1, 1995·Journal of Psychosomatic Research·A M Van Hemert
Jan 1, 1997·Annual Review of Immunology·J MacMickingC Nathan
Sep 26, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G Dusheiko
Nov 10, 1998·Journal of Psychopharmacology·P J Goodnick, B J Goldstein
Apr 9, 1999·Psychiatry Research·J G van Amsterdam, A Opperhuizen
Feb 26, 2000·Cardiovascular Research·P J Andrew, B Mayer
Jun 1, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P C TraskB Redman
Jun 1, 2000·The American Journal of Psychiatry·E DieperinkS B Ho
Mar 14, 2001·Journal of Affective Disorders·E SuzukiM Asai
Mar 16, 2001·Progress in Neurobiology·H Prast, A Philippu
Jun 5, 2001·Medical Hypotheses·E C Hurlock
Sep 29, 2001·Nature Immunology·C Bogdan
Mar 29, 2003·Pharmacy World & Science : PWS·Arthur R Van GoolAlexander M M Eggermont
Nov 8, 2003·The International Journal of Neuropsychopharmacology·Eiji SuzukiHitoshi Miyaoka
Nov 30, 2004·Nitric Oxide : Biology and Chemistry·Dimitrios Tsikas, Jürgen C Frölich
Dec 18, 2004·Nitric Oxide : Biology and Chemistry·Alastair M Mathewson, Roger M Wadsworth

❮ Previous
Next ❯

Citations

Oct 10, 2006·Neuropsychobiology·R HoekstraW M A Verhoeven
Mar 20, 2009·Journal of Neurosurgical Anesthesiology·Jaap W HolDurk Fekkes
May 7, 2014·The American Journal of the Medical Sciences·Joy N Jones Buie, Jim C Oates
Apr 19, 2008·Acta Anaesthesiologica Scandinavica·F WesseldijkF J Zijlstra
Jul 30, 2008·Protein Expression and Purification·Gaetano InvernizziMarina Lotti
May 1, 2020·Oxidative Medicine and Cellular Longevity·Anna ŁuczakAdrian Doroszko

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.