Influence of perioperative nalbuphine and fentanyl on postoperative respiration and analgesia

Acta Anaesthesiologica Scandinavica
N Rawal, M Wennhager

Abstract

In a double-blind study the relative postoperative respiratory and analgesic effects of perioperatively administered nalbuphine and fentanyl were compared in 60 females undergoing gynecological surgery under i.v. anesthesia. One milliliter (10 mg) nalbuphine was considered equipotent to 1 ml (100 micrograms) fentanyl. In the recovery period pain was assessed by visual analog score (VAS) and recovery by Pegboard scoring. Respiratory function was evaluated by continuous monitoring of respiratory frequency and end-tidal CO2 (ETCO2) and by frequent arterial blood gas analyses. The total volume of analgesic required for surgical analgesia was similar in the two groups. Patients in the nalbuphine group showed mild to moderate increases in pulse rate during the intubation phase and in blood pressure during surgery. Fentanyl was more effective in suppressing these cardiovascular responses. Within the first 15 min following recovery, increasing PaCO2 and ETCO2 as well as respiratory rates below 10/min were noted in 8 patients, who all belonged to the fentanyl group; in 4 of these patients i.v. naloxone had to be administered to reverse respiratory depression. Prolonged sedation was a common feature in patients receiving nalbuphine. It w...Continue Reading

References

Feb 4, 1978·British Medical Journal·A P Adams, D A Pybus
Mar 1, 1987·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·S K PanditM K Mathai
Nov 1, 1987·British Journal of Anaesthesia·G C PughC C Macintyre
Nov 1, 1987·Anesthesia and Analgesia·E K ZsigmondE Barabas
Jul 1, 1986·Canadian Anaesthetists' Society Journal·E Vatashsky, Y Haskel
Apr 1, 1974·JAMA : the Journal of the American Medical Association·G Y Tanaka
May 1, 1981·Clinical Pharmacology and Therapeutics·G LeeD T Mason
Apr 1, 1980·Clinical Pharmacology and Therapeutics·A Romagnoli, A S Keats
May 1, 1965·British Journal of Anaesthesia·M D VICKERS

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Citations

Jan 1, 1997·Diagnostic Cytopathology·D R SalomaoJ R Goellner
Nov 14, 2000·Diagnostic Cytopathology·K A Atkins
Apr 7, 2018·Pain Research & Management : the Journal of the Canadian Pain Society = Journal De La Société Canadienne Pour Le Traitement De La Douleur·Yu MaoErwei Gu
Apr 14, 2018·The American Journal of Hospice & Palliative Care·Mellar P DavisCarlos Fernandez

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