Influence of perioperative oxygen fraction on pulmonary function after abdominal surgery: a randomized controlled trial

BMC Research Notes
Anne K StaehrLars S Rasmussen

Abstract

A high perioperative inspiratory oxygen fraction (FiO2) may reduce the frequency of surgical site infection. Perioperative atelectasis is caused by absorption, compression and reduced function of surfactant. It is well accepted, that ventilation with 100% oxygen for only a few minutes is associated with significant formation of atelectasis. However, it is still not clear if a longer period of 80% oxygen results in more atelectasis compared to a low FiO2.Our aim was to assess if a high FiO2 is associated with impaired oxygenation and decreased pulmonary functional residual capacity (FRC). Thirty-five patients scheduled for laparotomy for ovarian cancer were randomized to receive either 30% oxygen (n = 15) or 80% oxygen (n = 20) during and for 2 h after surgery. The oxygenation index (PaO2/FiO2) was measured every 30 min during anesthesia and 90 min after extubation. FRC was measured the day before surgery and 2 h after extubation by a rebreathing method using the inert gas SF6. Five min after intubation, the median PaO2/FiO2 was 69 kPa [53-71] in the 30%-group vs. 60 kPa [47-69] in the 80%-group (P = 0.25). At the end of anesthesia, the PaO2/FiO2 was 58 kPa [40-70] vs. 57 kPa [46-67] in the 30%- and 80%-group, respectively (P = ...Continue Reading

References

Oct 1, 1977·British Journal of Anaesthesia·G B Drummond, D G Littlewood
Jan 1, 1992·Journal of Clinical Anesthesia·T D Egan, K C Wong
Apr 1, 1991·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·R W Wahba
Dec 1, 1988·Anesthesiology·R DueckT M Davidson
Jun 1, 1985·Journal of Applied Physiology·M C KallayC R Ortiz
Jun 1, 1994·Journal of Applied Physiology·P ClemensenJ Grønlund
Apr 1, 1994·Anesthesiology·G HedenstiernaB Brismar
Oct 1, 1996·Journal of Applied Physiology·L TokicsA Strandberg
Jan 7, 1999·The European Respiratory Journal·E ThorsenT B Aasen
Jul 31, 1999·Archives of Medical Research·I Maulen-RadovanM Márquez Aguirre
Aug 14, 2002·British Journal of Anaesthesia·J P WhiteleyC E W Hahn
Dec 13, 2002·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Anil AgarwalUttam Singh
Dec 28, 2002·Anesthesiology·L EdmarkG Hedenstierna
Jun 25, 2003·British Journal of Anaesthesia·Lennart Magnusson, Donat R Spahn
Nov 25, 2003·Anesthesia and Analgesia·Marco RuscaLennart Magnusson
Mar 31, 2005·Physiological Measurement·Philip J PeytonBruce Thompson
Oct 27, 2005·JAMA : the Journal of the American Medical Association·F Javier BeldaSpanish Reduccion de la Tasa de Infeccion Quirurgica Group
Sep 28, 2007·Diseases of the Colon and Rectum·Kelly A GendallFrank A Frizelle
Nov 9, 2007·Critical Care : the Official Journal of the Critical Care Forum·Dan S KarbingStephen E Rees
Jul 9, 2010·Best Practice & Research. Clinical Anaesthesiology·G Hedenstierna, L Edmark
Sep 9, 2010·The Cochrane Database of Systematic Reviews·Georgina ImbergerAnn Merete Møller
Nov 3, 2010·Acta Anaesthesiologica Scandinavica·L EdmarkG Hedenstierna
Mar 28, 2012·Current Opinion in Anaesthesiology·Christian S MeyhoffLars S Rasmussen
Apr 5, 2012·Acta Anaesthesiologica Scandinavica·G Hedenstierna

Citations

Nov 12, 2015·Indian Journal of Anaesthesia·Vijay Saraswat
Jan 24, 2018·American Journal of Veterinary Research·Manuel Martin-FloresRobin D Gleed
Oct 8, 2019·British Journal of Anaesthesia·Christopher C YoungJuraj Sprung

Clinical Trials Mentioned

NCT00637936

Related Concepts

Abdomen
Compression Pulmonary Atelectasis
Functional Residual Capacity
Lung
Ovarian Neoplasm
Dioxygen
Pulmonary Gas Exchange
Mechanical Ventilation
Gynecologic Surgical Procedures
Airway Extubation

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