Influence of peripheral O2 tension on the ventilatory response to CO2 in cats

Respiration Physiology
J H van BeekC N Olievier

Abstract

The effects of peripheral hypoxia on ventilation were investigated in 18 cats anaesthetized with chloralose urethane. The ponto-medullary region of the brain was artificially perfused via a cannulated vertebral artery, using an extracorporeal circuit fed from a femoral artery. In this way the carbon dioxide tension (PacCO2) and the oxygen tension in the blood supplying the brainstem could be imposed independently from the peripheral PCO2 (PapCO2) and PO2 (PapO2) in the systemic circulation. In all experiments the brainstem was kept hyperoxic. The steady-state ventilation VE could be described by (formula; see text) where Sp and Sc represent the peripheral and central sensitivity to carbon dioxide and K is a constant. Sc and K were independent of the PapO2. In general, peripheral hypoxia increased and peripheral hyperoxia decreased Sp, compared to normoxia. It is concluded that: (1) there is no interaction in the ventilatory response between peripheral O2-CO2 and central CO2 stimuli; and (2) a positive interaction in the ventilatory response between peripheral hypoxia and CO2 originates from the arterial chemoreceptors.

Citations

Nov 1, 1984·Pflügers Archiv : European journal of physiology·N Takano
Aug 1, 1984·Respiration Physiology·J H van BeekC N Olievier
Jan 1, 1984·Respiration Physiology·A BerkenboschP H Quanjer
Jun 1, 1989·Respiration Physiology·L Daristotle, G E Bisgard
Dec 1, 1989·Respiration Physiology·C N OlievierJ DeGoede
Mar 1, 1991·Respiration Physiology·L G OlsonN A Saunders
Apr 1, 1992·Respiration Physiology·I D ClementP A Robbins
Apr 1, 1994·Respiration Physiology·J G WolsinkC N Olievier
Oct 17, 1998·Respiration Physiology·S IscoeJ Duffin
Jun 1, 2013·Respiratory Physiology & Neurobiology·Philip N AinslieKeith R Burgess
Apr 28, 2010·The Journal of Physiology·Gregory M BlainJerome A Dempsey
Nov 22, 2011·Respiratory Physiology & Neurobiology·Z CuiJ Duffin
Mar 9, 2010·Respiratory Physiology & Neurobiology·Curtis A SmithJerome A Dempsey
Apr 17, 2007·Respiratory Physiology & Neurobiology·Peter A Robbins
Oct 1, 1987·Respiration Physiology·L DaristotleG E Bisgard
Nov 5, 2004·American Journal of Physiology. Cell Physiology·Robert W PutnamNicola A Ritucci
Apr 16, 2010·Physiological Reviews·Luc J Teppema, Albert Dahan
Dec 1, 1987·Archives of Disease in Childhood·J Milerad
Jun 16, 2001·Journal of Applied Physiology·J R RodmanC A Smith

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.