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Influence of pH, buffer species, and storage temperature on physicochemical stability of a humanized monoclonal antibody LA298

International Journal of Pharmaceutics

Dec 1, 2005

Jack Y Zheng, Linda J Janis

Abstract

The purpose of this work is to study the effect of pH, buffer species, and temperature on the physicochemical stability of a humanized monoclonal antibody LA298. The study was carried out in solution state of the antibody in the presence of different buffer species at different pH value...read more

Mentioned in this Paper

Buffers
Monoclonal Antibodies
Chinese Hamster
Asparagine
Biochemical Pathway
Covalent Interaction
IgG1 Antibody
Phosphate buffers
Citrate buffer
Aggregation
119
Paper Details
References
  • References5
  • Citations41
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Influence of pH, buffer species, and storage temperature on physicochemical stability of a humanized monoclonal antibody LA298

International Journal of Pharmaceutics

Dec 1, 2005

Jack Y Zheng, Linda J Janis

PMID: 16316730

DOI: 10.1016/j.ijpharm.2005.10.024

Abstract

The purpose of this work is to study the effect of pH, buffer species, and temperature on the physicochemical stability of a humanized monoclonal antibody LA298. The study was carried out in solution state of the antibody in the presence of different buffer species at different pH value...read more

Mentioned in this Paper

Buffers
Monoclonal Antibodies
Chinese Hamster
Asparagine
Biochemical Pathway
Covalent Interaction
IgG1 Antibody
Phosphate buffers
Citrate buffer
Aggregation
119

Trending Feeds

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Related Papers

Journal of Pharmaceutical and Biomedical Analysis

The effect of pH, hydrogen peroxide and temperature on the stability of human monoclonal antibody

Journal of Pharmaceutical and Biomedical AnalysisJune 1, 1996
A UsamiT Fujii
Analytical Chemistry

In vivo deamidation characterization of monoclonal antibody by LC/MS/MS

Analytical ChemistryMarch 1, 2005
Lihua HuangRalph M Riggin
Paper Details
References
  • References5
  • Citations41
12345
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