Nov 1, 1975

Influence of pH on the contractor effect of convulsant barbiturate on frog lung

Archives Internationales De Pharmacodynamie Et De Thérapie
H DownesN Gerber

Abstract

Pentobarbial, thiopental and the convulsant 5-ethyl-5-(2-cyclohexylideneëthyl) barbituric acid (CHEB) were tested for contractor effect on the isolated lung of the fullfrog at pH 7.0 (7% CO2 and 20 mM HCO3-) and pH 8.4 (0.3% CO2 and 20mM HCO3-). CHEB was a potent contractor, thiopental a feeble contractor, and pentobarbital lacked contractor effect. The contractor potencies of both CHEB and thiopental were greater at the more acid pH. The potencies of formally charged agonists such as acetylcholine and K+ were not altered by the pH differences employed in these experiments. The pKa of CHEB was found to be 8.18 at 15 degrees C and 8.03 at 27 degrees C. Calculation of concentration-effect relationships of ionized and nonionized CHEB showed that only the nonionized CHEB was responsible for the contractor effect.

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Mentioned in this Paper

5-(2-cyclohexylidene-ethyl)-5-ethylbarbiturate
Diabutal
Lung
Salientia
Potassium
Barbiturate [EPC]
Lung Diseases
Atropen
Barbituric acid salt
Inotropism

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