Influence of phenothiazines or reserpine on the formation of 14C-glycine from U-14C-serine

Enzyme
E GründigA Hawrylewicz

Abstract

The influence of the psychopharmaceuticals reserpine, thioproperazine and chlorpromazine on the synthesis of 14C-glycine from U-14C-serine was examined in a rat brain preparation. At low serine concentration (2 times 10(-5) mol/l) glycine synthesis in inhibited by all drugs tested probably due to the inhibition of the serine influx into mitochondria. At higher concentration (10(-3) mol/l) and physiological cofactor levels, phenothiazines increase to the measurable amount of 14C-glycine while reserpine has no effect. We assume that at this higher concentration serine transport through the mitochondrial membranes is no longer rate limiting; following phenothiazine action, the membrane-bound glycine cleavage system might be inhibited more strongly than the partly soluble serine hydroxymethyltransferase.

Citations

Oct 15, 1993·Biological Psychiatry·S BaruahA Sherman

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