PMID: 8938633Oct 1, 1996Paper

Influence of phospholipid on bile salt binding to calcium hydroxyapatite and on the poisoning of nascent hydroxyapatite crystals

Liver
M OkidoR S Crowther

Abstract

Glycine-conjugated, dihydroxy bile salts inhibit calcium hydroxyapatite (HAP) formation by binding to and poisoning nascent crystal embryos. Their taurine-conjugated counterparts bind less well to hydroxyapatite and do not inhibit its formation; but more hydrophobic, synthetic analogs of the taurine conjugated bile salts are inhibitors of hydroxyapatite formation. Because hydrophobicity is an important determinant of the ability of bile salts to inhibit hydroxyapatite crystal growth, experiments were performed to study the effect of the physiologically important mixed micelles of bile salt and phospholipid. Taurodeoxycholate/phosphatidylcholine (10:1) mixed micelles bound to HAP at lower total lipid concentrations than did pure taurodeoxycholate. At low total lipid concentrations, phosphatidylcholine (PC) binding appeared to predominate, suggesting that PC had a higher affinity than did taurodeoxycholate (TDC) for the HAP surface. Although glycodeoxycholate (3 mM) significantly (> 95%) inhibited hydroxyapatite precipitation, higher concentrations of taurodeoxycholate, either alone or mixed with phosphatidylcholine, did not affect hydroxyapatite formation. These results suggest that biliary phospholipids do not modulate the abil...Continue Reading

References

Aug 1, 1990·Seminars in Liver Disease·R S Crowther, R D Soloway
Nov 1, 1985·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C MarteauA Gerolami
Feb 1, 1988·Analytical Biochemistry·M T MoslenA E Ferguson
Jan 1, 1974·Methods in Enzymology·C Huang, T E Thompson
Mar 1, 1973·Gut·D J Sutor, S E Wooley

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Citations

Jan 23, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Kamyar Kalantar-ZadehJoel D Kopple

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