Influence of physical exercise and food restriction on the biomechanical properties of the femur of ageing male rats

Gerontology
Jesper Skovhus ThomsenAndrus Viidik

Abstract

Voluntary running in wheels as well as food reduction increase the life spans of rats. Disparate parameters such as the collagen biomarker of ageing and the development of kidney pathologies are decreased by voluntary exercise. There are few reports on the influence of physical exercise and food restriction on the skeleton of male rats. Most investigations initiated rather short-term interventions in 4- to 5-week-old animals and thus studied more the influence of growth than the influence of ageing on the skeleton. To compare the effects of physical exercise and food restriction on the biomechanical properties of bone tissue of ageing male rats with the interventions starting at the age of 5 months with the end point at 23 months. This enables the study of the influence of these interventions on the ageing of the skeleton. Five groups of male Sprague-Dawley rats were used: baseline (BL), voluntarily running in wheels (RW), food restriction to attain pair weight with RW animals (PW), forced running in treadmills (TM), and sedentary controls (SE). The biomechanical properties of femoral neck, diaphysis, and distal metaphysis were measured. While the body weights and fat-free mass increased from BL to SE group, the occiput-sacrum ...Continue Reading

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Citations

Sep 5, 2012·Experimental Biology and Medicine·Carol A EversonJeffrey M Toth
Apr 30, 2008·Experimental Gerontology·Wolfgang SiposPeter Pietschmann
Sep 27, 2020·Life·Hugues PortierStéphane Pallu

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