PMID: 9177587Feb 1, 1997Paper

Influence of physical exercise on old rats: changes in patterns of spontaneous activity and connective tissues

Aging : Clinical and Experimental Research
Andrus Viidik, Monika Skalicky

Abstract

It has been shown that life-long, regular physical exercise has benefits for humans as well as laboratory animals. Population studies have shown that the longevity of humans is increased due to the decrease in all-cause mortality. Further, the functional capacities of organ systems, especially the cardiovascular, are maintained better. Body fat content stays lower. Similar conclusions have been drawn from animal studies, most of them using voluntary exercise in running wheels. We have previously shown that spontaneous activity, measured in an open field setting, is better preserved, suggesting a slowing of sensorimotor impairment with age, and possibly improved maintenance of dopaminergic and cholinergic systems. Further, the systemic effect on connective tissues was a slowing of the age-dependent increase of stability by changes in the cross-linking patterns. The purpose of the present investigation was to analyze whether late-onset training programs had any such effects, i.e., whether the aging effects seen in sedentary animals could be reversed to some extent. We trained male Sprague-Dawley rats from the age of 18 and 20 months until the age of 22 months, i.e., for 4 and 2 months, in a treadmill for 800 m/day. Spontaneous ac...Continue Reading

References

Feb 1, 1979·Mechanisms of Ageing and Development·A Viidik
Nov 3, 1989·JAMA : the Journal of the American Medical Association·S N BlairL W Gibbons
Nov 1, 1988·Journal of Gerontology·J O Holloszy
Mar 6, 1986·The New England Journal of Medicine·R S PaffenbargerC C Hsieh
Sep 1, 1985·Journal of Applied Physiology·J O HolloszyS Adams
Aug 15, 1968·Experientia·A Viidik
Sep 1, 1982·Journal of Gerontology·J F Marshall
Jan 1, 1982·Experimental Gerontology·A P WagnerL P Wagner
Jul 17, 1996·Mechanisms of Ageing and Development·A ViidikM Skalicky

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Citations

Mar 17, 1999·Aging : Clinical and Experimental Research·R D LipmanR T Bronson
Feb 13, 2004·Aging Clinical and Experimental Research·Andrus Viidik, Monika Skalicky
May 1, 1991·Mechanisms of Ageing and Development·A Quirinia, A Viidik
Nov 19, 2005·Scandinavian Journal of Medicine & Science in Sports·M V NariciN Reeves
Jun 22, 2017·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Kenneth Ladd SeldeenBruce Robert Troen
Nov 28, 2017·PloS One·Jennifer C ArnoldMichael F Salvatore

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