Influence of plaque calcium on neointimal hyperplasia following bare metal and drug-eluting stent implantation

Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions
Yoshihisa ShimadaPeter J Fitzgerald

Abstract

To examine the influence of vessel wall calcium on neointimal hyperplasia (NIH) following bare metal stent (BMS) and drug-eluting stent (DES) implantation. While procedural complications with coronary stenting in calcified lesions are well reported, little is known about subsequent NIH on plaque calcium following either BMS or DES implantation. In the Study to COmpare REstenosis Rate between QueST and QuaDDS-QP2 (SCORE) trial, 6 months follow-up volumetric intravascular ultrasound data were available for 41 lesions (BMS, 19; DES, 22). NIH thicknesses on superficial, deep, and noncalcified plaque were calculated at every 0.5 mm intervals over the stented segment. Calcified and less-calcified cross-sections were defined as those containing arcs of plaque calcium > or = 90 degrees and < 90 degrees , respectively. In BMS, mean NIH thickness on both superficial (0.24 +/- 0.23 mm) and deep calcium (0.25 +/- 0.21 mm) was significantly smaller than that of noncalcified plaque (0.31 +/- 0.22 mm) (P < 0.0005). NIH area was significantly smaller in calcified cross-sections compared to less-calcified cross-sections (2.1 +/- 1.2 mm2 vs. 3.1 +/- 1.9 mm2, P < 0.0001). While in contrast, in DES, mean NIH thickness was similar, irrespective of ...Continue Reading

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Citations

Jun 7, 2011·Journal of Vascular and Interventional Radiology : JVIR·Il Soo ChangYoung Wook Kim
Oct 14, 2014·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Christos V BourantasHector M Garcia-Garcia
Apr 14, 2015·Cardiovascular Revascularization Medicine : Including Molecular Interventions·Parloop BhattKeyur Parikh
Feb 18, 2014·Journal of the American College of Cardiology·Mahesh V MadhavanPhilippe Généreux
Apr 29, 2014·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Christos V BourantasPatrick W Serruys
Apr 18, 2015·JACC. Cardiovascular Imaging·Gary S Mintz

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