PMID: 11924725Apr 2, 2002Paper

Influence of plasma aldosterone on left ventricular geometry and diastolic function in treated essential hypertension

Hypertension Research : Official Journal of the Japanese Society of Hypertension
Yoshio IwashimaYuhei Kawano

Abstract

Since aldosterone is known to promote interstitial fibrosis in cardiac tissues, it is possible that aldosterone may influence cardiac structure and function. In the present study, we investigated whether plasma aldosterone concentration (PAC) is related to the distinct patterns of left ventricular (LV) geometry and LV diastolic function in treated essential hypertension. In 92 patients with chronically treated essential hypertension, two-dimensional and Doppler echocardiographic examinations were performed and LV inflow velocities were measured for evaluation of LV diastolic function. When patients were divided into four groups by the different LV geometric patterns, PAC in patients with eccentric hypertrophy was significantly higher than in those with concentric hypertrophy (15.2+/-2.1 vs. 10.0+/-0.7 ng/dl, p<0.01). However, the ratio of the peak velocity of early diastolic filling to that of atrial filling (EIA), an index of LV diastolic function, was significantly decreased in patients with concentric hypertrophy compared with those showing normal geometry. In the relationship between PAC and LV diastolic function, PAC was negatively correlated with EIA (r=-0.35, p<0.05) only in the subgroup with normal relative wall thickne...Continue Reading

References

Jun 1, 1992·Journal of the American College of Cardiology·A GanauJ H Laragh
Jan 1, 1991·Circulation·H E Morgan, K M Baker
Feb 1, 1991·Journal of the American College of Cardiology·A C PearsonA J Labovitz
Dec 1, 1989·Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension·P GranierF Galinier
Apr 1, 1982·European Heart Journal·R C TaraziP Khairallah
Jun 1, 1984·Journal of the American College of Cardiology·F M FouadR C Tarazi
Jan 1, 1984·The American Journal of Cardiology·I InouyeJ Tubau
Dec 1, 1981·The Journal of Endocrinology·J StaessenA Amery
Apr 21, 1982·The American Journal of Cardiology·P LijnenA Amery
Mar 15, 1995·Journal of the American College of Cardiology·H M KrumholzD Levy
Jun 1, 1994·The Journal of Clinical Investigation·M YoungJ Funder
Sep 1, 1996·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·H RakowskiC Tomlinson
Dec 1, 1996·European Heart Journal·B AndrénH Lithell
Mar 1, 1997·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Y YoshitomiT Omae
Apr 30, 1999·Hypertension Research : Official Journal of the Japanese Society of Hypertension·A SatoT Saruta
Mar 29, 2000·Hypertension Research : Official Journal of the Japanese Society of Hypertension·A SatoT Saruta
Jul 27, 2000·Hypertension Research : Official Journal of the Japanese Society of Hypertension·M SasaguriK Arakawa

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Citations

Nov 13, 2008·Circulation·Raghava S VelagaletiRamachandran S Vasan
Apr 26, 2007·Circulation Journal : Official Journal of the Japanese Circulation Society·Takao NakaharaAkira Yamashina
Jun 9, 2007·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Dawood DarbarDan M Roden
May 25, 2005·Diabetic Medicine : a Journal of the British Diabetic Association·J MiyazatoY Kawano
Jun 17, 2006·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Hidenobu KawamotoNobuyo Maeda
Jul 24, 2002·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Junko MiyazatoYuhei Kawano
Apr 27, 2007·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Min PanXiang-Jun Yang
Apr 27, 2007·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Roberto FogariAmedeo Mugellini
Sep 6, 2005·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Mohammad SaeedPhilippe M Frossard
Sep 15, 2005·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Kaoru YoshidaHiroshi Iwao
Jan 14, 2004·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Chinami OgataYuhei Kawano
Jul 20, 2005·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Akira KurataJitsuo Higaki
Jan 9, 2015·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Giuseppe MulèSantina Cottone
Oct 25, 2011·Journal of Cardiovascular Disease Research·O E AjayiM O Balogun
May 31, 2012·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Tomás IndraJirí Widimsky
Oct 7, 2009·Laboratory Investigation; a Journal of Technical Methods and Pathology·Yoshichika BabaHiromi Rakugi
Aug 17, 2018·The Journal of Clinical Endocrinology and Metabolism·Christian AdolfMartin Reincke

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