Influence of PMN leukocyte-mediated pancreatic damage on the systemic immune response in severe acute pancreatitis in rats

Digestive Diseases and Sciences
Uwe A WittelB Poch

Abstract

The outcome of severe acute pancreatitis is determined by the development of the systemic inflammatory response and subsequent multiorgan dysfunction. Using the taurocholate-induced model of acute pancreatitis in rats, we investigated the relationship between early polymorphonuclear (PMN)-mediated pancreatic tissue damage and the systemic inflammatory response. The respiratory burst of PMN leukocytes was increased in animals with acute pancreatitis and was reduced by anti-ICAM-1 antibody and oxygen radical scavenger treatment after 24 hr. In acute pancreatitis a reduced number of peripheral helper T cells was evident, most likely due to L-selectin-mediated increased lymphocyte homing. After 24 hr the CD45RC(high)/CD45RC(low) ratio of helper T cells, a critical factor in T cell-mediated disease was increased due to a reduction of regulatory CD45RC(low) cells. Only the treatment with anti-ICAM-1 mAb affected these changes, indicating that immunological changes in necrotizing pancreatitis are only in part affected by early PMN leukocyte-mediated pancreatic damage.

Citations

Oct 5, 2011·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Basem AzabWarren D Widmann
May 12, 2016·Journal of Hepato-biliary-pancreatic Sciences·Lan PengLi-Ming Wen
Jan 11, 2019·BioMed Research International·Chenyuan ShiYi Miao
Dec 11, 2014·World Journal of Gastroenterology : WJG·Jing LiCheng-Wei Tang

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