Influence of polyclonal anti-thymocyte globulins upon ischemia-reperfusion injury in a non-human primate model

Transplant Immunology
Andres Beiras-FernandezE Thein

Abstract

Polyclonal anti-thymocyte globulins (ATGs) are used to induce immunosuppression and to treat acute rejection after transplantation. ATGs induce apoptosis and in peripheral T-lymphocytes having the potential to inhibit leukocyte adhesion. We analysed the influence of three different ATGs upon the microvasculature and the different cell-subpopulations after ischemia/reperfusion (IRI). Extremities of cynomolgus monkeys were surgically isolated and flushed with Ringer's lactate at 4 degrees C. After 60 min of ischemia the limbs were reperfused with matching human blood. ATGs were added to the blood 30 min prior to the reperfusion. Four groups were generated: Tecelac-ATG group, Fresenius(S)-ATG group, Thymoglobulin-ATG group and a control group. Blood analyses were performed in blood samples taken after the beginning of the reperfusion. Biopsies from muscular tissue were obtained after the experiments. The number of circulating leukocytes was lower in the ATG-groups than in control. Morpho-cytological analyses showed depletion of peripheral lymphocytes. Histological examination showed less tissue damage, reduced presence of fibrin and adherent thrombocytes in the ATG-treated groups. Leukocyte infiltration, both in muscle and vascula...Continue Reading

References

Nov 1, 1981·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S M Hsu, L Raine
Jan 1, 1984·Cell and Tissue Research·T BärJ R Wolff
Nov 26, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M ThielK Messmer
Dec 29, 1998·Transplantation Proceedings·N Bonnefoy-BérardJ P Revillard
Dec 29, 1998·Transplantation Proceedings·S Massberg, K Messmer
Sep 22, 1999·Gene Therapy·N GiannoukakisP Robbins
Nov 18, 2000·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·M D Menger, B Vollmar
May 1, 2001·Xenotransplantation·E TheinK Messmer
Sep 5, 2001·Journal of Vascular Surgery·M M FarooqJ A Freischlag
Apr 30, 2002·Seminars in Immunology·Francis W LuscinskasSunil K Shaw
Aug 15, 2002·Transplantation Proceedings·Bernard Charpentier, UNKNOWN European Tacrolimus vs Microemulsified Cyclosporin Study Group
Jan 28, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Shawn D St PeterDavid C Mulligan
Mar 18, 2003·Transplantation·Marie-Cécile MichalletJean-Pierre Revillard

❮ Previous
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Citations

Nov 26, 2008·Transplantation Reviews·Douglas LinfertHamid Rabb
Oct 4, 2007·Annals of the New York Academy of Sciences·Simon D LyttonAchim M Nutzenberger
Mar 17, 2012·Transplant International : Official Journal of the European Society for Organ Transplantation·Eugenia K PageStuart J Knechtle
Oct 16, 2012·Clinical Transplantation·Georges MouradYvon Lebranchu
May 7, 2011·Transplant International : Official Journal of the European Society for Organ Transplantation·Sistiana AielloMarina Noris
Sep 28, 2010·The Annals of Thoracic Surgery·Samuel B GoldfarbGary Visner
Dec 24, 2014·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J B HalldorsonJ Reyes
Oct 9, 2014·Immunological Investigations·Mark Reza LaftaviOleh Pankewycz
Jan 18, 2014·Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia·Sailaja KesirajuS Sahariah
Oct 3, 2012·Transplantation Proceedings·A P TrevizolL A C D'Albuquerque
Oct 3, 2012·Transplantation Proceedings·L R Requião-MouraA Pacheco-Silva
Aug 30, 2016·Transplant International : Official Journal of the European Society for Organ Transplantation·Jamila KremerBruno K Podesser
May 21, 2015·Einstein·Lúcio Roberto Requião-MouraAlvaro Pacheco-Silva
Jul 31, 2007·Drugs·Nicole A Weimert, Rita R Alloway
Jul 13, 2007·The Journal of Trauma·Eric Elster
Sep 13, 2008·Seminars in Cutaneous Medicine and Surgery·Guy F Webster, Emmy M Graber

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