Influence of polymeric additives on the cohesion and mechanical properties of calcium phosphate cements

Journal of Materials Science. Materials in Medicine
Jie AnSander C G Leeuwenburgh

Abstract

To expand the clinical applicability of calcium phosphate cements (CPCs) to load-bearing anatomical sites, the mechanical and setting properties of CPCs need to be improved. Specifically, organic additives need to be developed that can overcome the disintegration and brittleness of CPCs. Hence, we compared two conventional polymeric additives (i.e. carboxylmethylcellulose (CMC) and hyaluronan (HA)) with a novel organic additive that was designed to bind to calcium phosphate, i.e. hyaluronan-bisphosphonate (HABP). The unmodified cement used in this study consisted of a powder phase of α-tricalcium phosphate (α-TCP) and liquid phase of 4% NaH2PO4·2H2O, while the modified cements were fabricated by adding 0.75 or 1.5 wt% of the polymeric additive to the cement. The cohesion of α-TCP was improved considerably by the addition of CMC and HABP. None of the additives improved the compression and bending strength of the cements, but the addition of 0.75% HABP resulted into a significantly increased cement toughness as compared to the other experimental groups. The stimulatory effects of HABP on the cohesion and toughness of the cements is hypothesized to derive from the strong affinity between the polymer-grafted bisphosphonate ligands ...Continue Reading

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Citations

Nov 28, 2016·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Claire I A van HoudtJeroen J J P van den Beucken
Jan 23, 2018·Bone Research·Hockin Hk XuMark A Reynolds
Mar 23, 2019·Nanotechnology·Charng-Gan TuChih-Chung C C Yang
Mar 11, 2021·Journal of the Mechanical Behavior of Biomedical Materials·Ammar Z AlshemaryZafer Evis
Jul 7, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Hanan MoussaFaleh Tamimi

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BETA
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scanning electron microscopy

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GraphPad Instat
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