Influence of polyphenolic extracts from Enydra fluctuans on oxidative stress induced by acephate in rats

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Sanjukta DattaSantinath Ghosh

Abstract

Acephate, an organophosphorus pesticide, has been proved to play an important role in tissue damage by inducing oxidative stress through the release of free radicals. The aim of this study was to evaluate the protective effect of the plant phenolic compounds present in Enydra fluctuans against acephate toxicity based on lipid peroxidation and antioxidant enzymes profile in rats. An oral dose of acephate at 30 mg/kg of body weight has been given against the extracts containing 20mg of polyphenolic compounds (expressed as gallic acid equivalents)/kg body weight for 14 days. The results showed that under the influence of the pesticides, there was significant decrease in the activities of the antioxidant enzymes SOD, Catalase and Glutathione peroxidase (GPx) and an increase in the non-enzymatic Glutathione, with respect to the normal and the plant extract gavaged groups. Also that there was an increase in the plasma and erythrocyte membrane lipid peroxidation levels in the pesticide treated group compared to the normal or the group treated with the plant extract. The present study thus gives an insight into the ill-effects of this organophosphate and the protective role of plant polyphenols in minimizing those effects.

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Citations

Mar 7, 2014·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Yurong HouChanghao Sun
Jan 11, 2011·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Riadh BadraouiTarek Rebai
Jul 11, 2012·Environmental Toxicology·Carmine Inês Acker, Cristina Wayne Nogueira
May 3, 2014·Toxicology Mechanisms and Methods·Mohamed Montassar LasramNajoua Gharbi
Jun 2, 2012·Oxidative Medicine and Cellular Longevity·B Poljsak, I Milisav
Dec 6, 2012·Toxicology and Industrial Health·Amit R BhadaniyaHarish H Savsani
Apr 11, 2017·Journal of Toxicology·M A Thamali Dhanushka, L Dinithi C Peiris
Jun 1, 2021·Chemico-biological Interactions·Sharmistha ChoudhuriShailendra Asthana

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