PMID: 11907176Mar 22, 2002Paper

Influence of porcine Actinobacillus pleuropneumoniae infection and dexamethasone on the pharmacokinetic parameters of enrofloxacin

The Journal of Pharmacology and Experimental Therapeutics
Lynn O PostMichael J Myers

Abstract

The impact of Actinobacillus pleuropneumoniae (APP) infection in swine on the pharmacokinetic parameters of enrofloxacin were determined. Twenty-four animals were used in a 2 x 2 factorial of treatment groups (six animals per group) to determine the impact of APP-induced inflammation and the anti-inflammatory drug dexamethasone on enrofloxacin pharmacokinetic parameters. All animals received enrofloxacin as a single intravenous dose (5 mg/kg). Administration of dexamethasone was associated with an increase in clearance of enrofloxacin Clearance of enrofloxacin was not affected by APP. Volume of distribution at steady state was significantly increased in the dexamethasone-treated pigs. Volume of distribution at steady state was decreased by APP infection. Dexamethasone significantly increased the terminal elimination half-life of enrofloxacin. APP infection decreased the terminal elimination half-life of enrofloxacin in the infected pigs. Infection and dexamethasone significantly decreased the urine enrofloxacin/creatinine and ciprofloxacin/creatinine ratios. This study shows that APP infection does affect plasma pharmacokinetic parameters. Dexamethasone and APP infection may reduce renal clearance of enrofloxacin with a compens...Continue Reading

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Citations

Dec 30, 2008·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Robert P Hunter, Ramiro Isaza
Oct 27, 2004·Journal of Veterinary Pharmacology and Therapeutics·M PeyrouA Bousquet-Mélou
Jun 11, 2004·Journal of Veterinary Pharmacology and Therapeutics·S K CoxJ Bartges
Sep 15, 2006·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·M ElmasA Er Karabacak
Jun 19, 2010·Journal of Veterinary Pharmacology and Therapeutics·M Martinez, S Modric
Sep 4, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Sven DänickeHermann-Josef Rothkötter
Jul 6, 2016·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Rubén Pérez-FernándezRafael A Burgos
Jan 23, 2003·The Journal of Pharmacology and Experimental Therapeutics·Lynn O PostMichael J Myers
Nov 9, 2019·Tropical Animal Health and Production·Pritam K SidhuJohann F Coetzee
Jun 7, 2020·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Marilyn N MartinezMatt Kuhn
Nov 26, 2016·Journal of Veterinary Pharmacology and Therapeutics·J W SparksJ F Coetzee

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