PMID: 7512673Apr 1, 1994Paper

Influence of portal branch ligation on the outcome of repeat dearterializations of an experimental liver tumor in the rat

Journal of Surgical Oncology
L Q WangS Bengmark

Abstract

It has been suggested that the portal vein should be occluded during intermittent hepatic dearterialization in order to induce a more complete ischemia of the tumor. In this experiment the influence of portal branch ligation in combination with repeat dearterializations on a liver tumor was investigated. Twenty-seven rats were randomly allocated to sham treatment (n = 6); portal branch ligation (PBL) (n = 7); 120 min of repeat dearterialization (n = 7); and portal branch ligation (PBL) in combination with 50 min of repeat dearterialization (n = 7) (once a day during 5 days). The results showed that portal branch ligation alone did not alter the tumor growth compared with sham treatment (P > 0.05), nor did portal branch ligation in combination with repeat dearterializations for 50 min (P > 0.05). However, tumor growth delay was achieved following 120 min of repeat dearterializations without occlusion of the portal branch (P < 0.01 versus all the other groups). There was a significant weight loss of the lobe undergoing PBL, whether dearterialization was added or not (P < 0.001). The liver nucleotide/DNA and RNA/DNA ratio significantly decreased as well. Histological examination showed that > 50% of tumor cells became necrotic aft...Continue Reading

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Citations

Nov 1, 1996·Cardiovascular and Interventional Radiology·J HarnekH Stridbeck
Nov 7, 2003·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·J RothbarthL J Schultze Kool
Apr 3, 2007·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·L B J van IerselC J H van de Velde
Apr 15, 2006·Expert Review of Anticancer Therapy·J RothbarthC J H van de Velde
Oct 22, 2002·The Journal of Pharmacology and Experimental Therapeutics·Joost RothbarthGerard J Mulder

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