Influence of Postoperative Intraocular Pressure on Graft Detachment After Descemet Membrane Endothelial Keratoplasty

Cornea
Sonja HeinzelmannPhilip Maier

Abstract

Descemet membrane endothelial keratoplasty (DMEK) seems to be the most promising technique for treating endothelium-related disorders of the cornea. However, graft detachment is a frequent complication. It often can be treated by rebubbling procedures. Unfortunately, this increases the risk of subsequent graft failure. It is therefore essential to define risk factors for graft detachment in DMEK. In this study, postoperative intraocular pressure (IOP) is investigated in this regard. In total, 1047 DMEK procedures in patients with Fuchs endothelial dystrophy or bullous keratopathy were reviewed. All rebubbling procedures were recorded as well as postoperative IOP values (first measure 2 hours postoperatively and highest and lowest value within 3 days after surgery), donor factors (donor age, organ culture time, and endothelial cell count), and whether DMEK surgery had been combined with cataract surgery (triple-DMEK). Incidence rates were estimated with the Kaplan-Meier method. Cox regression was used to assess statistical significance. The overall rebubbling rate was 24% after 8 weeks. Relative dips in IOP may be associated with a higher risk for graft detachment (hazards ratio = 0.41; P < 0.001). Graft detachment was neither s...Continue Reading

References

Jun 28, 2011·Ophthalmology·Ursula Schlötzer-SchrehardtFriedrich E Kruse
Mar 9, 2012·American Journal of Ophthalmology·Theofilos TourtasFriedrich E Kruse
Jan 30, 2015·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Anna-Karina B MaierNecip Torun
Jul 29, 2015·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·T RöckE Yörük
Dec 29, 2015·Survey of Ophthalmology·Andrew M J TurnbullDavid F Anderson
Jan 9, 2016·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·S HeinzelmannP Maier
Aug 16, 2016·American Journal of Ophthalmology·Friederike SchaubBjörn O Bachmann

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Citations

Jan 24, 2019·Cornea·Sonja HeinzelmannPhilip Maier
Jul 28, 2020·The British Journal of Ophthalmology·Hon Shing OngJodhbir Mehta
Jan 6, 2021·The British Journal of Ophthalmology·Rashmi DeshmukhRasik B Vajpayee
Feb 19, 2021·The British Journal of Ophthalmology·Suryan DunkerUNKNOWN Dutch Cornea Consortium

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