Influence of Postprandial Intragastric Pressures on Drug Release from Gastroretentive Dosage Forms

AAPS PharmSciTech
Felix SchneiderWerner Weitschies

Abstract

Despite extensive research in the field of gastroretentive dosage forms, this "holy grail" of oral drug delivery yet remained an unmet goal. Especially under fasting conditions, the reproducible retention of dosage forms in the stomach seems to be an impossible task. This is why such systems are often advised to be taken together with food. But also the postprandial motility can contribute significantly to the failure of gastroretentive dosage forms. To investigate the influence of postprandial pressure conditions on drug release from such systems, we used a novel in vitro dissolution tool, the dissolution stress test device. With the aid of this device, we simulated three different intragastric pressure profiles that may occur after postprandial intake. These transit scenarios were based on recently obtained, postprandial SmartPill® data. The tested systems, Glumetza® 1000 and Madopar® HBS 125, are marketed dosage forms that are based on different approaches to achieve proper gastric retention. All three transit scenarios revealed a highly pressure-sensitive drug release behavior, for both drugs. For Madopar® HBS 125, nearly complete drug release was observed even after early occurring pressures. Glumetza® 1000 seemed to be mo...Continue Reading

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Citations

Aug 21, 2019·Pharmaceutics·Felix SchneiderWerner Weitschies
Aug 21, 2019·AAPS PharmSciTech·Gábor VasváriFerenc Fenyvesi
Aug 21, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Marco NeumannWerner Weitschies

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MotiliGI®
OriginPro
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