Influence of posture on transient lower oesophageal sphincter relaxation and gastro-oesophageal reflux in the dog

Journal of Gastroenterology and Hepatology
A F LittleR Lavelle

Abstract

The hypothesis that suppression of transient lower oesophageal sphincter relaxation (TLOSR) in recumbent postures in the dog is dependent upon the sensing of a gastric pool of liquid in proximity to the lower oesophageal sphincter was examined. Constant gastric insufflation with air (80 ml/min) was used to evoke TLOSR in unsedated, fasting animals. Oesophageal motility was monitored with a perfused manometric sleeve catheter assembly. Gastrooesophageal flow was recognized manometrically and by oesophageal pH recording. TLOSR occurred significantly less frequently in three recumbent positions (right lateral, left lateral and supine) than when the dog stood on four legs, but was more likely to be associated with acid reflux when they occurred in recumbent positions. Aspiration of the gastric pool was found to have no effect on triggering of TLOSR although it reduced the frequency with which acid reflux was associated with TLOSR. It is concluded that the low rate of occurrence of TLOSR in recumbent positions is unlikely to be explained by the presence of a gastric pool of liquid in proximity to the lower oesophageal sphincter.

References

May 1, 1987·Gastroenterology·S KnuhtsenO V Nielsen
Dec 16, 1982·The New England Journal of Medicine·W J DoddsM S Egide
Feb 1, 1980·The Journal of Clinical Investigation·J DentD J Petrie

❮ Previous
Next ❯

Citations

Jul 14, 2012·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Akash ShuklaShobna J Bhatia
Dec 26, 2001·The American Journal of Medicine·R H Holloway
Dec 1, 2001·European Journal of Pharmacology·A Lehmann, L Brändén
Jun 1, 1990·Gut·J B WymanJ Downton
Oct 31, 2002·American Journal of Respiratory and Critical Care Medicine·Frank ZerbibJ Manuel Tunon-De-Lara
Sep 27, 2000·Baillière's Best Practice & Research. Clinical Gastroenterology·R H Holloway
May 13, 1999·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J Stakeberg, A Lehmann
Mar 4, 2000·The Australian and New Zealand Journal of Surgery·M R CoxC J Martin
Oct 12, 2019·Acta Paediatrica·Paolo QuitadamoAnnamaria Staiano
Jun 14, 2020·Journal of Veterinary Internal Medicine·Megan E GrobmanCarol R Reinero
Jan 14, 2005·Gastroentérologie Clinique Et Biologique·Thierry Piche

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.