Influence of potassium ions and osmolality on the resting membrane potential of rabbit ventricular papillary muscle with estimation of the activity and the activity coefficient of internal potassium.

Circulation Research
T Akiyama, H A Fozzard

Abstract

Resting membrane potentials of rabbit right ventricular papillary muscles were measured in modified Tyrode's solutions that were isotonic (1.0 X T), hypertonic (1.58 X T), or hypotonic (0.76 X T) at eight different concentrations of external potassium, [K]o, ranging from 0.78 to 100 mM. The amount of hyperpolarization produced by exposure to the hypertonic solutions was relatively constant with an average of 4.6 mv at all levels of [K]o except 0.78 and 1.56 mM. This potential change is much less than the 10.6 mv which would be predicted if the papillary muscles behaved as nearly perfect osmometers and the activity coefficient of intracellular potassium (K) remained constant. The amount of depolarization produced by exposure to the 0.76 X T hypotonic solutions averaged 6.8 mv at all levels of [K]o except 0.78 mM; this value is close to the predicted value of 6.9 mv. Variations in the activity and the activity coefficient of intracellular K were introduced to explain these discrepancies. We estimated that the activity of intracellular K in 1.58 X T hypertonic solution was increased 15-23% compared with that in isotonic solution. This change is much less than the 58% that would be predicted if the papillary muscle behaved as a nea...Continue Reading

References

Jun 1, 1975·The Journal of General Physiology·C O Lee, H A Fozzard
Jun 1, 1972·The Journal of General Physiology·K HermsmeyerN Sperelakis
Jul 1, 1972·Physiological Reviews·R C Thomas
Nov 1, 1971·The Journal of General Physiology·W R Gibbons, H A Fozzard
Oct 1, 1971·Journal of Molecular and Cellular Cardiology·N Sperelakis, R Rubio
Mar 1, 1966·The Journal of General Physiology·E Page, S R Storm
Jul 1, 1961·The Journal of Physiology·O F HUTTER, D NOBLE
Oct 1, 1959·The Journal of Physiology·A L HODGKIN, P HOROWICZ

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Citations

Aug 28, 2003·Clinical and Experimental Pharmacology & Physiology·Toshitsugu OguraSunao Imanishi
Jan 1, 1994·Transplant International : Official Journal of the European Society for Organ Transplantation·M SunamoriA Suzuki
May 24, 2001·Transplant International : Official Journal of the European Society for Organ Transplantation·M SunamoriH Tanaka
Jul 17, 2010·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Rob F WiegerinckJuan Cinca
Oct 16, 2015·Wiener klinische Wochenschrift·Ferhat DenizArif Yonem
Jul 21, 2009·Journal of Pharmacological and Toxicological Methods·Liang GuoHeather Guthrie
Jun 6, 2009·Journal of Pharmacological and Toxicological Methods·Armando Pérez de PradoFelipe Fernández-Vázquez
Sep 29, 2000·American Journal of Physiology. Heart and Circulatory Physiology·F BretteJ Y Le Guennec
Nov 1, 1993·The American Journal of Physiology·D W WhalleyH H Rasmussen
Jan 5, 2000·Physiological Reviews·J R HumeB Horowitz
Aug 1, 1997·The American Journal of Physiology·J I VandenbergT Powell
Jan 1, 1981·The American Journal of Physiology·E Ruiz-CerettiJ P Caille

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