Influence of potent antioxidant leguminosae family plant extracts on growth and antioxidant defense system of Hep2 cancer cell line

Journal of Medicinal Food
Chrysoula SpanouDemetrios Kouretas

Abstract

Legumes are considered to be a very good source of polyphenolic compounds that may act as chemopreventive agents, especially by their antioxidant properties. However, many of the chemopreventive properties may depend on the concentrations of the phytochemical compounds because potent antioxidant polyphenolic compounds may have pro-oxidant properties and negatively affect cell growth and viability. Thus, the aim of the present study was to assess the possible effect of two potent antioxidant Greek Leguminosae family plant extracts on the growth of a specific cancer cell line and its antioxidant defense cell system. Aqueous extracts of aerial parts of Lathyrus laxiflorus and Phaseolus vulgaris plants were initially examined for their cytotoxicity on the Hep2 cancer cell line at concentrations that possess potent antioxidant properties (100, 400, and 800 microg/mL). After a 24-hour incubation with the extracts, only L. laxiflorus plant extract exhibited the ability to inhibit the cell growth at 400 and 800 microg/mL by 57% and 74%, respectively, whereas P. vulgaris extract had no effect on cell growth at any of the tested concentrations. Noncytotoxic concentrations, 100 microg/mL L. laxiflorus and 800 microg/mL P. vulgaris extract...Continue Reading

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Jul 19, 2008·Journal of Agricultural and Food Chemistry·Chrysoula SpanouDemetrios Kouretas

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Citations

Oct 11, 2011·Journal of Physiology and Biochemistry·Chrysoula I SpanouDimitrios Kouretas
Jul 19, 2011·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·I AbeteJ A Martínez
Sep 4, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·P N ShilpaS Niranjali Devaraj
Mar 7, 2017·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·E J Llorent-MartínezA Aktumsek
Jul 18, 2018·Molecular Medicine Reports·Changjiang LiMin Chen
Aug 17, 2021·Nutrition and Cancer·Deepa S Mandlik, Satish K Mandlik

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