Influence of pre-anaesthetic medication on target propofol concentration using a 'Diprifusor' TCI system during ambulatory surgery

Anaesthesia
M StruysG Rolly

Abstract

The effects of pre-anaesthetic medication on target propofol concentration, induction dose, time to induction, and discomfort on infusion were studied in 45 female patients undergoing ambulatory gynaecological procedures using 'Diprifusor' target controlled infusion of propofol. The patients were randomly allocated to receive either no premedication (group 1) or premedication with diazepam alone (group 2) or in combination with alfentanil (group 3). Induction was more successful in premedicated than unpremedicated patients with an initial target propofol concentration of 4 micrograms.ml-1 (87% in group 2 and 93% in group 3 vs. 38% in group 1, p < 0.01). Premedication was also associated with the requirement of a lower mean target concentration for induction, a lower induction dose and a shorter time to induction. There were no significant between-group differences in discomfort on infusion or target concentration during maintenance. For short ambulatory procedures, the recommended initial target concentration of propofol is 4 micrograms.ml-1 in premedicated and 6 micrograms.ml-1 in unpremedicated patients.

Citations

Apr 21, 1999·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·A CasatiG Torri
Jul 31, 2012·Current Infectious Disease Reports·Ilker UçkayDaniel Lew
Oct 29, 2002·The Pediatric Infectious Disease Journal·Sandra J Murray, Jay M Lieberman
Dec 24, 2004·Anesthesia and Analgesia·Hiroko IwakiriDaniel I Sessler
Jul 5, 2011·Revista brasileira de anestesiologia·Ricardo Francisco SimoniPedro Thadeu Galvão Vianna
Nov 14, 2002·Anaesthesia·S KarthikeyanM Parsloe

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