Influence of Preformed Antibodies in Liver Transplantation

Journal of Clinical Medicine
Isabel LegazManuel Muro

Abstract

The significance of human leukocyte antigen (HLA) matching and preformed donor-specific antibodies (DSAs) in liver transplantation remains unclear. The aim of this study was to analyze the presence of DSAs in a large cohort of 810 liver recipients undergoing liver transplant to determine the influence on acute (AR) or chronic liver rejection (CR), graft loss and allograft survival. DSAs were identified using complement dependent cytotoxicity crossmatch (CDC-CM) and multiplexed solid-phase-based flow cytometry assay (Luminex). CDC-CM showed that a 3.2% of liver transplants were positive (+CDC-CM) with an AR frequency of 19.2% which was not different from that observed in negative patients (-CDC-CM, 22.3%). Only two patients transplanted with +CDC-CM (7.6%) developed CR and suffered re-transplant. +CDC-CM patients showed a significantly lower survival rate compared to -CDC-CM patients (23.1% vs. 59.1%, p = 0.0003), developing allograft failure within the first three months (p < 0.00001). In conclusion, we have demonstrated a relationship between the presence of preformed DSAs and the low graft liver survival, indicating the important role and the potential interest of performing this analysis before liver transplantation. Our res...Continue Reading

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Citations

Oct 7, 2020·Transplant International : Official Journal of the European Society for Organ Transplantation·Barbora KovandovaPavel Trunecka
Oct 21, 2020·Clinics and Research in Hepatology and Gastroenterology·Manuel Muro
Oct 27, 2020·Current Opinion in Organ Transplantation·Steven C Kim, David P Foley

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Methods Mentioned

BETA
biopsies
flow cytometry

Software Mentioned

Microsoft Access
SPSS

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