Influence of preoperative chemoradiotherapy on the number of lymph nodes retrieved in rectal cancer

Annals of Surgery
Yun Hyung HaJae-Gahb Park

Abstract

To evaluate the relation of preoperative chemoradiotherapy to the number of lymph nodes retrieved in curative intent surgery for rectal cancer. Current guidelines recommend evaluation of least 12 to 14 lymph nodes in rectal cancer. It is well known that lymph nodes retrieval is affected by many factors. This was a retrospective study of 615 patients who underwent curative intent surgery for primary rectal cancer. Preoperative chemoradiotherapy involving 50.4 Gy fractionated radiotherapy and concurrent chemotherapy was performed in patients with locally advanced rectal cancer (clinically T3 or T4). We explored associations between the number of lymph nodes retrieved in the pathologic specimen and patient demographics (age, gender, body mass index [BMI]), treatment (surgeon, sphincter-saving, preoperative chemoradiotherapy), and tumor-related variables (location, stage, histology). After adjustment for other factors, we compared the mean number of obtained lymph nodes between patients treated with preoperative chemoradiotherapy and those treated without preoperative chemoradiotherapy. Univariate analysis demonstrated that age, BMI, preoperative chemoradiotherapy, location, and stage significantly related the number of lymph nodes...Continue Reading

References

Jan 1, 1997·International Journal of Colorectal Disease·O DworakA Hoffmann
Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J H WongT S Namiki
Jan 3, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J E TepperR J Mayer
Sep 8, 2001·The New England Journal of Medicine·E KapiteijnUNKNOWN Dutch Colorectal Cancer Group
Mar 5, 2002·Archives of Surgery·Matthias W WichmannFriedrich W Schildberg
Oct 7, 2003·Annals of Surgical Oncology·F C WrightA J Smith
Oct 8, 2003·Pathology Oncology Research : POR·Dénes GörögFerenc Perner
Mar 3, 2004·Journal of Clinical Pathology·N ScottD Jayne
Sep 1, 2004·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·C C ThornN S Ambrose
Oct 22, 2004·The New England Journal of Medicine·Rolf SauerUNKNOWN German Rectal Cancer Study Group
Jan 22, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Leopoldo SarliLuigi Roncoroni
Jan 26, 2005·International Journal of Radiation Oncology, Biology, Physics·Nancy N BaxterJoel E Tepper
Feb 3, 2005·Journal of the National Cancer Institute·Nancy N BaxterBeth A Virnig
Mar 23, 2005·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·S-B LimJ-G Park
Oct 5, 2006·Diseases of the Colon and Rectum·Paris P TekkisUNKNOWN Association of Coloproctology of Great Britain and Ireland
Nov 14, 2006·International Journal of Radiation Oncology, Biology, Physics·Dae Yong KimJae-Gahb Park
Dec 26, 2006·International Journal of Radiation Oncology, Biology, Physics·Frederic BibeauDavid Azria
Jun 20, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Eva Judith Ann MorrisPhilip Quirke
Dec 29, 2007·The American Journal of Surgical Pathology·Anne RullierEric Rullier

❮ Previous
Next ❯

Citations

Feb 2, 2012·Der Pathologe·I Tischoff, A Tannapfel
May 24, 2012·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Daniel C DaminGilberto Schwartsmann
Dec 16, 2010·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Asunción Hervás MorónEduardo Lobo Martínez
Oct 13, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Anand GovindarajanGarrett M Nash
Apr 5, 2013·World Journal of Gastroenterology : WJG·Shao-Chieh LinJenq-Chang Lee
Aug 6, 2014·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·In Ja ParkJin Cheon Kim
Oct 25, 2013·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Mi-Joo ChungMi-Ryeong Ryu
Dec 27, 2015·Annals of Diagnostic Pathology·Gülçin YegenMine Güllüoğlu
Jul 28, 2012·Gastrointestinal Endoscopy·Sanne A L BartelsWillem A Bemelman
Jan 10, 2012·Journal of the American College of Surgeons·Jinru ShiaDavid S Klimstra
Jan 10, 2012·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·I S MartijnseD K Wasowicz-Kemps
Jan 21, 2012·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·J L DikkenD G Coit
Sep 11, 2012·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·G E H AwwadN A Rieger
Dec 18, 2013·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·J LykkeUNKNOWN Danish Colorectal Cancer Group
Oct 29, 2015·BioMed Research International·Monirath HavClaude A Cuvelier
Feb 6, 2015·International Journal of Colorectal Disease·Jakob LykkeUNKNOWN Danish Colorectal Cancer Group
Jul 2, 2016·Clinical Colorectal Cancer·Leonardo S Lino-SilvaÁngel Herrera-Gómez
Apr 8, 2017·Journal of Cancer Research and Clinical Oncology·Wen-Hua FanPei-Rong Ding
Mar 31, 2012·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Peter A S JohnstoneMichael G Moore
Feb 23, 2018·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Peng GaoZhenning Wang
Jul 29, 2018·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Naruhiko IkomaBrian D Badgwell
Nov 12, 2014·Annals of Surgical Oncology·Jong Hoon LeeDae Kyung Sohn
Jun 18, 2015·American Journal of Clinical Oncology·Seung Yeop OhKwang Wook Suh
Aug 10, 2012·Diseases of the Colon and Rectum·Eric D MillerPeter A S Johnstone

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