Influence of preoperative radiotherapy on head and neck free-flap reconstruction: Systematic review and meta-analysis.

Head & Neck
Ainiwaer MijitiMuhetaer Huojia

Abstract

The effect of preoperative external radiotherapy (XRT) on head and neck free-flap reconstruction is still controversial. In this study, we aimed to determine the impact of preoperative XRT on the outcomes of head and neck microvascular free-flap reconstruction. A systematic review and meta-analysis was conducted in concordance with the Systematic reviews and Meta-Analyses protocol. We searched several databases (PubMed, EMBASE, Web of Science, and Cochrane Library) to find published papers on the topic. The R program was used for data synthesis and statistical heterogeneity evaluation; then, fixed effect or random effect models were used. A total of 37 studies, involving 12 408 patients with 12 668 flaps, were included in this meta-analysis. The overall flap success rate for all studies was 94.4%. Pooled analysis showed that patients with preoperative XRT were significantly associated with an increased risk of total flap failure (odds ratio [OR] = 1.80, 95% confidence interval [CI] = 1.45-2.23, P < .001), partial flap failure (OR = 1.90, 95% CI = 1.07-3.38, P = .029), and postoperative complication rates (OR = 2.22, 95% CI = 1.64-2.72, P < .001). Our study suggests that preoperative XRT is associated with an increased risk of d...Continue Reading

References

Oct 1, 1991·American Journal of Surgery·J L KienerS J Mathes
Aug 1, 1984·Plastic and Reconstructive Surgery·P J GuelinckxJ A Gruwez
Oct 1, 1984·American Journal of Surgery·R J TabahJ C Banis
Sep 1, 1993·Plastic and Reconstructive Surgery·S MulhollandJ Yoo
Feb 9, 1999·Plastic and Reconstructive Surgery·B SinghJ P Shah
Sep 15, 2004·Auris, Nasus, Larynx·Munenaga NakamizoToshiaki Yagi
Nov 17, 2004·Archives of Otolaryngology--head & Neck Surgery·Seungtaek ChoiNeal Futran
Jun 10, 2005·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Samuel LinHarold Pelzer
Jun 20, 2006·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·K Bozikov, Z M Arnez
Apr 29, 2008·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·M HalleC Arnander
Oct 24, 2008·Microsurgery·Matthew M HanasonoRoman J Skoracki
Nov 22, 2008·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·David L HirschBryce E Potter
Jul 22, 2009·Archives of Facial Plastic Surgery·Michael J NuaraDaniel S Alam
Aug 25, 2009·Auris, Nasus, Larynx·Seiichi YoshimotoHiroki Mitani
Sep 8, 2009·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Cornelia Katharina Mueller, Stefan Schultze-Mosgau
May 13, 2010·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Young-Hoon JooMin-Sik Kim
Jul 8, 2010·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Sooyeon Lee, Christin Thiele
Jul 26, 2011·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Arash MomeniGordon K Lee
Jan 29, 2013·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·M J BenatarA Bozec
Oct 31, 2014·Plastic and Reconstructive Surgery·Tomer AvrahamJamie P Levine
Aug 25, 2015·Oncology Nursing Forum·Mark Vrabel
Feb 7, 2016·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Miho IshimaruHideo Yasunaga
Jun 19, 2016·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Claudio RostetterAstrid L Kruse
Aug 17, 2016·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Thomas MückeDenys J Loeffelbein
Apr 19, 2017·International Journal of Oral and Maxillofacial Surgery·W ZhouX Peng
Jun 26, 2018·American Journal of Otolaryngology·Mofiyinfolu SokoyaYadranko Ducic

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