Influence of preparation methodology on solid-state properties of an acidic drug-cyclodextrin system

The Journal of Pharmacy and Pharmacology
Ramprakash Govindarajan, M S Nagarsenker

Abstract

We have investigated the influence of processing variables on the solid-state of a model drug, flurbiprofen, in cyclodextrin-based systems and its effect on dissolution behaviour of the drug. The interaction between flurbiprofen and hydroxypropyl beta-cyclodextrin (HP-beta-CyD) was studied by NMR spectroscopy and phase solubility studies. Binary systems containing flurbiprofen and HP-beta-CyD or povidone (polyvinylpyrrolidone) K30, prepared by various processes, were characterized by FTIR, DSC, XRD and dissolution studies. HP-beta-CyD enhanced the solubility of flurbiprofen and increased dissolution rates from binary systems. It was found to be superior to povidone K30 in producing higher dissolution rates. The method of preparation of the binary systems and the agents used were found to have a major influence on the final solid-state of flurbiprofen. Solvents and processing conditions favouring greater interaction between flurbiprofen and the cyclodextrin during the preparation process resulted in greater extent of drug-cyclodextrin association and/or greater amorphization of the drug. Use of ammonia during the preparation of binary systems yielded solids from which very rapid drug dissolution was achieved, due to a higher ext...Continue Reading

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Citations

Apr 24, 2008·AAPS PharmSciTech·Aditya Dinge, Mangal Nagarsenker
May 19, 2011·The Journal of Pharmacy and Pharmacology·Flávia Pires MaximianoMarcílio S S Cunha-Filho
Dec 31, 2011·Pharmaceutical Development and Technology·Adel A Ali, Ossama M Sayed
Aug 4, 2016·Drug Development and Industrial Pharmacy·Gurunath SurampalliParagouda A Patil
Nov 3, 2010·The Journal of Pharmacy and Pharmacology·Thorsteinn Loftsson, Marcus E Brewster
Mar 22, 2005·Pharmaceutical Development and Technology·Ramprakash Govindarajan, Mangal S Nagarsenker
Sep 24, 2009·Pharmaceutical Development and Technology·Praful Balavant DeshpandeSurenalli G Vasanth

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