Influence of probe flexibility and gelatin embedding on neuronal density and glial responses to brain implants

PloS One
Per KöhlerCecilia Eriksson Linsmeier

Abstract

To develop long-term high quality communication between brain and computer, a key issue is how to reduce the adverse foreign body responses. Here, the impact of probe flexibility and gelatine embedding on long-term (6w) tissue responses, was analyzed. Probes of same polymer material, size and shape, flexible mainly in one direction, were implanted in rat cerebral cortex (nimplants = 3 x 8) in two orientations with respect to the major movement direction of the brain relative to the skull: parallel to (flex mode) or transverse to (rigid mode). Flex mode implants were either embedded in gelatin or non-embedded. Neurons, activated microglia and astrocytes were visualized using immunohistochemistry. The astrocytic reactivity, but not microglial response, was significantly lower to probes implanted in flex mode as compared to rigid mode. The microglial response, but not astrocytic reactivity, was significantly smaller to gelatin embedded probes (flex mode) than non-embedded. Interestingly, the neuronal density was preserved in the inner zone surrounding gelatin embedded probes. This contrasts to the common reports of reduced neuronal density close to implanted probes. In conclusion, sheer stress appears to be an important factor for...Continue Reading

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Citations

Aug 11, 2016·Journal of Nanobiotechnology·Lina GällentoftCecilia Eriksson Linsmeier
Feb 12, 2017·Acta Biomaterialia·Zhanhong Jeff DuX Tracy Cui
May 5, 2017·Journal of Neural Engineering·Heui Chang LeeKevin J Otto
Jun 24, 2017·IEEE Transactions on Bio-medical Engineering·Heui Chang LeeKevin J Otto
Jun 18, 2019·Advanced Materials·Nikita ObidinCanan Dagdeviren
Dec 23, 2017·Frontiers in Neuroscience·Katarzyna M SzostakTimothy G Constandinou
Jan 11, 2018·Scientific Reports·Andrew J ShoffstallJeffrey R Capadona
Apr 1, 2021·Neurochemistry International·Buket Ucar
Dec 16, 2020·ACS Biomaterials Science & Engineering·Brian J O'GradyEthan S Lippmann

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BETA
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Software Mentioned

NIS Elements
NIS
GraphPad
Elements BR
GraphPad Prism

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