Influence of prostacyclin infusion on haemodialysis efficiency and blood cells

International Urology and Nephrology
M Kuźniewski, W Sułowicz


Dialysis efficiency, platelet and leukocyte counts, as well as malonyldialdehyde (MDA) level and lactate dehydrogenase (LDH) activity in serum were assessed in 10 patients (8 males, 2 females, aged 28-58 years) treated with repeated haemodialysis due to terminal renal failure. Patients were examined twice: during a 4-hour haemodialysis in the presence of heparin as the anticoagulant, and a week later in the course of another haemodialysis combined with infusion of heparin and prostacyclin. Statistically significant lower level of urea at the end of dialysis and significantly higher urea clearance were found during haemodialysis with prostacyclin-heparin infusion in comparison with infusion of heparin alone. As compared with the initial values obtained prior to dialysis, neutropenia and thrombocytopenia were observed during haemodialysis with heparin alone but the counts remained generally unaltered when both prostacyclin and heparin were administered. During and after haemodialysis with heparin and prostacyclin both MDA level and LDH activity were lower than in case of haemodialysis with heparin alone.


Nov 15, 1978·Clinica Chimica Acta; International Journal of Clinical Chemistry·K Satoh
Jan 1, 1991·International Urology and Nephrology·M KuźniewskiJ Lisiewicz
Apr 1, 1989·Angiology·M Camici, L Evangelisti
Jan 1, 1986·American Journal of Nephrology·A K Cheung, L W Henderson
Apr 1, 1985·The American Journal of Medicine·R M Hakim, A I Schafer
Oct 1, 1973·Clinical Science and Molecular Medicine·C ThomsonC R Prentice
May 16, 1981·Lancet·J H TurneyM J Weston
Jul 1, 1983·British Medical Bulletin·M J Weston
Sep 1, 1984·The American Journal of Medicine·N D VaziriE Hung
Jun 1, 1982·Pharmacological Research Communications·A Dembińska-KiećT Zelazny
Nov 1, 1982·The American Journal of Medicine·M C SmithM J Dunn
Jul 1, 1980·The Annals of Thoracic Surgery·J R PlachetkaJ G Copeland
Apr 16, 1981·The New England Journal of Medicine·R M ZusmanN Tolkoff-Rubin
Oct 1, 1980·Kidney International·A I JacobJ J Bourgoignie
Apr 1, 1981·Archivos De Farmacología Y Toxicología·G EscolarM R Hernández
Jan 1, 1980·Journal of Dialysis·J ShinM Nishioka

Related Concepts

Kidney Failure, Chronic
Lactate Dehydrogenase
Differential White Blood Cell Count Procedure
Sodium Malondialdehyde
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