Influence of prostacyclin infusion on haemodialysis efficiency and blood cells

International Urology and Nephrology
M Kuźniewski, W Sułowicz

Abstract

Dialysis efficiency, platelet and leukocyte counts, as well as malonyldialdehyde (MDA) level and lactate dehydrogenase (LDH) activity in serum were assessed in 10 patients (8 males, 2 females, aged 28-58 years) treated with repeated haemodialysis due to terminal renal failure. Patients were examined twice: during a 4-hour haemodialysis in the presence of heparin as the anticoagulant, and a week later in the course of another haemodialysis combined with infusion of heparin and prostacyclin. Statistically significant lower level of urea at the end of dialysis and significantly higher urea clearance were found during haemodialysis with prostacyclin-heparin infusion in comparison with infusion of heparin alone. As compared with the initial values obtained prior to dialysis, neutropenia and thrombocytopenia were observed during haemodialysis with heparin alone but the counts remained generally unaltered when both prostacyclin and heparin were administered. During and after haemodialysis with heparin and prostacyclin both MDA level and LDH activity were lower than in case of haemodialysis with heparin alone.

References

Nov 15, 1978·Clinica Chimica Acta; International Journal of Clinical Chemistry·K Satoh
Jan 1, 1991·International Urology and Nephrology·M KuźniewskiJ Lisiewicz
Apr 1, 1989·Angiology·M Camici, L Evangelisti
Jan 1, 1986·American Journal of Nephrology·A K Cheung, L W Henderson
Apr 1, 1985·The American Journal of Medicine·R M Hakim, A I Schafer
Oct 1, 1973·Clinical Science and Molecular Medicine·C ThomsonC R Prentice
May 16, 1981·Lancet·J H TurneyM J Weston
Jul 1, 1983·British Medical Bulletin·M J Weston
Sep 1, 1984·The American Journal of Medicine·N D VaziriE Hung
Jun 1, 1982·Pharmacological Research Communications·A Dembińska-KiećT Zelazny
Nov 1, 1982·The American Journal of Medicine·M C SmithM J Dunn
Jul 1, 1980·The Annals of Thoracic Surgery·J R PlachetkaJ G Copeland
Apr 16, 1981·The New England Journal of Medicine·R M ZusmanN Tolkoff-Rubin
Oct 1, 1980·Kidney International·A I JacobJ J Bourgoignie
Apr 1, 1981·Archivos De Farmacología Y Toxicología·G EscolarM R Hernández
Jan 1, 1980·Journal of Dialysis·J ShinM Nishioka

Related Concepts

Hemodialysis
Liquaemin
Kidney Failure, Chronic
Lactate Dehydrogenase
Differential White Blood Cell Count Procedure
Sodium Malondialdehyde
Platelet Count Measurement
Flolan

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.