Influence of proton pump inhibitor use in gastrointestinal polyps

The Kaohsiung Journal of Medical Sciences
Wen-Hung HsuFang-Jung Yu

Abstract

Proton pump inhibitors (PPIs) are the most potent anti-acid agents and are extensively used worldwide. PPI-induced hypergastrinemia is one of the very few side effects associated with these drugs. However, because hypergastrinemia is related to the occurrence of colonic adenomatous polyps, the purpose of this study was to analyze the relationship between the occurrence of gastrointestinal polyps and hypergastrinemia induced by PPIs. This study included 259 patients who underwent colonoscopy and esophagogastroduodenoscopy between January and August 2007. Chart records, including medication history and fasting plasma gastrin level, were reviewed and analyzed. Any subtle polypoid lesions in the stomach and colon were sampled by biopsy for histological examination. Helicobacter pylori infection status was examined by a rapid urea test during esophagogastroduodenoscopy. All patients underwent endoscopy examinations. A total of 122 patients were receiving PPI treatment for either peptic ulcer disease or reflux esophagitis and were included as the study group. The remaining 137 patients were not treated with PPIs and served as the non-PPI group. The mean fasting gastrin level in PPI users versus non-PPI users was 121.8 ng/L versus 56....Continue Reading

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Citations

Apr 1, 2011·Clinical Journal of Gastroenterology·T P Rakesh
Nov 2, 2012·Korean journal of family medicine·Jeong Soo AhnSeung-Kwon Myung
May 24, 2016·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·An Tran-DuyCoen D A Stehouwer
Sep 17, 2016·Alimentary Pharmacology & Therapeutics·F C MartinN D Yeomans
Jul 26, 2019·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Chan Young JeongDong Ho Lee
May 16, 2019·Histopathology·Masahide FukudaRyoji Kushima
Nov 18, 2017·Digestive Diseases and Sciences·Amnon SonnenbergRobert M Genta

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