Influence of puberty timing on adiposity and cardiometabolic traits: A Mendelian randomisation study.

PLoS Medicine
Joshua A. BellGeorge Davey Smith

Abstract

Earlier puberty is widely linked with future obesity and cardiometabolic disease. We examined whether age at puberty onset likely influences adiposity and cardiometabolic traits independent of childhood adiposity. One-sample Mendelian randomisation (MR) analyses were conducted on up to 3,611 white-European female and male offspring from the Avon Longitudinal Study of Parents and Children (ALSPAC) cohort recruited at birth via mothers between 1 April 1991 and 31 December 1992. Time-sensitive exposures were age at menarche and age at voice breaking. Outcomes measured at age 18 y were body mass index (BMI), dual-energy X-ray absorptiometry-based fat and lean mass indices, blood pressure, and 230 cardiometabolic traits derived from targeted metabolomics (150 concentrations plus 80 ratios from nuclear magnetic resonance [NMR] spectroscopy covering lipoprotein subclasses of cholesterol and triglycerides, amino acids, inflammatory glycoproteins, and others). Adjustment was made for pre-pubertal BMI measured at age 8 y. For negative control MR analyses, BMI and cardiometabolic trait measures taken at age 8 y (before puberty, and which therefore cannot be an outcome of puberty itself) were used. For replication analyses, 2-sample MR was...Continue Reading

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Citations

May 10, 2020·Annals of Human Biology·Ahmed EhakeemDeborah A Lawlor
Oct 16, 2019·The Journal of Clinical Endocrinology and Metabolism·Min Cao, Bin Cui
Sep 5, 2020·Human Molecular Genetics·Diana L Cousminer, Rachel M Freathy
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Jun 30, 2021·The Journal of Clinical Endocrinology and Metabolism·Jemina KiveläSaila B Koivusalo
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Nov 27, 2021·Paediatric and Perinatal Epidemiology·Kun HuangCecilia Høst Ramlau-Hansen
Aug 25, 2021·Cold Spring Harbor Perspectives in Medicine·Rebecca C Richmond, George Davey Smith

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Methods Mentioned

BETA
chip
X-ray
nuclear magnetic resonance

Software Mentioned

PLINK
TwoSampleMR
GIANT
R
Studio

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