Influence of PVP/VA copolymer composition on drug-polymer solubility

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
Malte Bille RaskThomas Rades

Abstract

In this study, the influence of copolymer composition on drug-polymer solubility was investigated. The solubility of the model drug celecoxib (CCX) in various polyvinylpyrrolidone/vinyl acetate (PVP/VA) copolymer compositions (70/30, 60/40, 50/50 and 30/70 w/w) and the pure homopolymers polyvinylpyrrolidone (PVP) and polyvinyl acetate (PVA) was predicted at 25 °C using a thermal analysis method based on the recrystallization of a supersaturated amorphous dispersion (recrystallization method). These solubilities were compared with a prediction based on the solubility of CCX in the liquid monomeric precursors of PVP/VA, N-vinylpyrrolidone (NVP) and vinyl acetate (VA), using the Flory-Huggins lattice theory (liquid monomer solubility approach). The solubilities predicted from the liquid monomer solubility approach increased linearly with increasing VP/VA ratio from 0.03-0.60 w/w. Even though the solubilities predicted from the recrystallization method also increased with increasing VP/VA ratio from 0.02-0.40 w/w, the predicted solubility seemed to approach a plateau at high VP/VA ratios. Increasing positive deviations from the Gordon-Taylor equation with increasing VP/VA ratio indicated strong interactions between CCX and the VP r...Continue Reading

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Citations

Mar 26, 2016·Journal of Pharmaceutical Sciences·Matthias Manne KnoppThomas Rades
Jun 9, 2016·Expert Opinion on Drug Delivery·Tu Van Duong, Guy Van den Mooter
Apr 9, 2017·Journal of Pharmaceutical Sciences·Kevin DeBoyace, Peter L D Wildfong
Mar 22, 2018·Pharmaceutical Development and Technology·Bayan AlemrayatHusam M Younes
Sep 20, 2018·Journal of Microencapsulation·Jingjing TangWeike Su
May 28, 2021·Molecular Pharmaceutics·Samarth D ThakoreArvind K Bansal
Jun 19, 2021·AAPS PharmSciTech·Marta F SimõesSérgio Simões

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