Influence of quasispecies on virological responses and disease severity in patients with chronic hepatitis C.

World Journal of Gastroenterology : WJG
Deepak KumarPremashis Kar

Abstract

To elucidate the influence of quasispecies on virological response and disease severity in patients with chronic hepatitis C. Forty seven patients with hepatitis C [32 with chronic active hepatitis (CAH), 9 with cirrhosis, and 6 with hepatocellular carcinoma (HCC)] were screened for the presence of quasispecies by single stranded conformational polymorphism (SSCP) analysis in the hypervariable region (HVR) and non-structural 5B (NS5B) viral genes of hepatitis C virus. The 41 patients excluding those with HCC were on therapy and followed up for a year with the determination of virological response and disease severity. Virus isolated from twenty three randomly selected patients (11 non-responders and 12 showing a sustained virological response) was sequenced for the assessment of mutations. The occurrence of quasispecies was proportionately higher in patients with HCC and cirrhosis than in those with CAH, revealing a significant correlation between the molecular evolution of quasispecies and the severity of disease in patients with hepatitis C. The occurrence of complex quasispecies has a significant association (P < 0.05) with the non-responders, and leads to persistence of infection. Significant differences (P < 0.05) in viral...Continue Reading

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Jan 29, 2011·Vojnosanitetski pregled. Military-medical and pharmaceutical review·Nada Kuljić-KapulicaRadmila Rajić
Sep 30, 2021·Annual Review of Virology·Esteban DomingoCelia Perales

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