Influence of race on prenatal phthalate exposure and anogenital measurements among boys and girls

Environment International
Abby G WenzelRoger B Newman

Abstract

Select phthalates have antiandrogenic activity, which raises concern for adverse developmental outcomes given widespread exposure of pregnant women. Investigators have reported associations between maternal urinary phthalates and altered anogenital distance (AGD), a marker of in utero androgen activity, among offspring. However, data assessing the impact of race on these associations is sparse. To evaluate associations between prenatal phthalate exposure and AGD in a racially diverse newborn population. We prospectively collected second trimester urine from 187 African American and 193 white mothers, and used liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) to measure eight phthalate metabolites and calculate molar sums. We measured anopenile (APD) and anoscrotal (ASD) distances of 171 boys and anoclitoral (ACD) and anofourchette (AFD) distances of 128 girls at delivery. We collected sociodemographic and clinical data from questionnaires and delivery records. We identified a statistically significant inverse association for mono-2-ethylhexyl phthalate (MEHP) and APD in boys (B=-1.57mm, p=0.02), which was stronger for African Americans (B=-2.07mm, p=0.04) than for whites (B=-1.23mm, p=0.22), although the raci...Continue Reading

Citations

Jan 9, 2020·Current Opinion in Pediatrics·Lauren M PetrickWilliam E Funk
May 13, 2020·Pediatric Research·Rachana ShahVirginia A Stallings
May 19, 2019·Bulletin of Environmental Contamination and Toxicology·Perry W BartschJohn W Brock
Jan 25, 2020·Environmental Science and Pollution Research International·Jian-Qing WangFang-Biao Tao
Sep 29, 2020·Frontiers in Public Health·Yiyu QianYing Hua
Oct 23, 2019·Current Environmental Health Reports·Emily S Barrett, Amy M Padula
Feb 15, 2021·International Journal of Hygiene and Environmental Health·Min LuanWei Yuan
Mar 7, 2021·International Journal of Environmental Research and Public Health·Mary E SterrettRoger B Newman
Jun 17, 2020·Environmental Science & Technology·Congqiao YangMiriam L Diamond
Oct 8, 2021·Molecular Reproduction and Development·Inês MesquitaElisa Cairrao
Sep 24, 2021·Annual Review of Pharmacology and Toxicology·Akhgar GhassabianLeonardo Trasande

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