Influence of raising albumin concentration on renin release in isolated perfused rat kidneys

The Journal of Physiology
J C Fray, A S Karuza

Abstract

1. Experiments were conducted in isolated perfused rat kidneys to determine the effect of raising perfusate albumin concentration on renin release.2. Raising albumin concentration in the perfusion fluid from 20 g/l. to 60 g/l. (high albumin concentration) increased renin release and renal perfusate flow rate. The effect was reversible.3. Ureteral occlusion did not prevent the rise in renin release and renal perfusate flow induced by high albumin concentration.4. Propranolol (0.28 mM) did not block the renin release stimulated by high albumin concentration, but it inhibited the release stimulated by isoprenaline (2.43 muM).5. Clonidine (10 muM) and oxymetazoline (10 muM) constricted the renal vasculature and stimulated renin release during high perfusate albumin concentration providing perfusion pressure was kept constant.6. Low renal perfusion pressure (50 mmHg) and isoprenaline (2.43 muM) stimulated renin release in perfusion experiments with both 20 and 60 g/l., but the rate of renin release was substantially greater with 60 g/l.7. On the other hand, perfusion fluid deprived of calcium induced a greater increase in renin release in kidneys perfused with 20 g/l. than in those with 60 g/l.8. We conclude that high albumin concen...Continue Reading

Citations

Oct 1, 1982·Kidney International·J S Carvalho
Sep 1, 1985·Pflügers Archiv : European journal of physiology·S G RostandR G Luke
Feb 7, 1983·Life Sciences·A S Al-Naji, D E Clarke

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.