Influence of rapid tryptophan depletion on laboratory-provoked aggression in children with ADHD

Neuropsychobiology
C StadlerFritz Poustka

Abstract

The present study investigated the effects of rapid tryptophan depletion (RTD), and the ensuing reduction of central nervous system levels of serotonin (5-HT), upon reactive aggression in patients with attention deficit/hyperactivity disorder (ADHD). Furthermore, it was asked whether the relation between 5-HT function and behavioural aggression in patients is influenced by their age, the intensity of their attention problems or their comorbid symptoms. The study employed a double-blind, within-subject crossover design. On day 1, 22 male adolescent patients with ADHD were subjected to RTD and the subsequent reduction of central 5-HT levels. On day 2, they received a tryptophan-balanced amino acid mixture (BAL), which acted as a placebo. On both days, 4.5 h after the intake of the RTD/BAL amino acids, reactive aggressive behaviour was provoked using a competitive reaction time game, which consisted of both high and low provocation conditions. The number of aggressive responses was significantly higher after low provocation during acute tryptophan depletion, in comparison to the placebo. Furthermore, this study provides evidence that neither age nor the intensity of attention symptoms in ADHD patients had an impact on the relation...Continue Reading

References

Jan 1, 1992·Psychopharmacology·A Biegon, N Greuner
Nov 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·M S LidowP Rakic
Sep 1, 1987·Journal of the American Academy of Child and Adolescent Psychiatry·A J Zametkin, J L Rapoport
Sep 1, 1988·Journal of the American Academy of Child and Adolescent Psychiatry·S R PliszkaT Broussard
Mar 1, 1982·The American Journal of Psychiatry·G A RogenessE L Mitchell
Oct 1, 1994·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·P M Whitaker-AzmitiaC Clarke
Jan 1, 1995·Journal of the American Academy of Child and Adolescent Psychiatry·G L HannaJ K Coates
Feb 1, 1994·The American Journal of Psychiatry·J M HalperinJ H Newcorn
Jul 1, 1996·Psychopharmacology·F G MoellerD R Cherek
Nov 15, 1996·Psychiatry Research·C W HughesG L Kramer
Oct 6, 1997·Biological Psychiatry·A S UnisJ Mitchell
Mar 19, 1999·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·S H van GoozenH van Engeland
Jun 8, 1999·Psychiatry Research·R A ClarkeJ N Constantino
Sep 4, 1999·Brain, Behavior and Evolution·L A FairbanksJ J Mann
Mar 4, 2000·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·J M BjorkA C Swann
Mar 18, 2000·Advances in Experimental Medicine and Biology·S N YoungC Benkelfat
Nov 7, 2000·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·P MooreJ C Gillin
Dec 17, 2002·Journal of Abnormal Child Psychology·Daniel A WaschbuschHoward B Moss
Sep 15, 2004·Neuropsychobiology·C StadlerF Poustka

❮ Previous
Next ❯

Citations

Feb 27, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Simon N Young
Jun 16, 2011·PloS One·Amélie Nantel-VivierJean R Séguin
Feb 23, 2013·Journal of Psychiatry & Neuroscience : JPN·Simon N Young
Jun 19, 2009·The Journal of Nutrition, Health & Aging·L Volicer
May 6, 2015·CNS Spectrums·Daniel R Rosell, Larry J Siever
Feb 17, 2015·Neurochemistry International·Emili Banerjee, Krishnadas Nandagopal
Nov 18, 2018·Acta Psychiatrica Scandinavica·Kevin C RunionsFlorian D Zepf
Nov 20, 2008·Journal of Neural Transmission·Florian Daniel ZepfF Poustka
Sep 13, 2011·Journal of Marriage and the Family·Robin S Högnäs, Marcia J Carlson
Jan 23, 2018·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Caroline S HildebrandtFlorian D Zepf
Mar 23, 2009·International Journal of Tryptophan Research : IJTR·Dawn M RichardDonald M Dougherty
Nov 22, 2016·Acta Psychiatrica Scandinavica·G P BorgsF D Zepf
Dec 19, 2016·Food & Nutrition Research·Maike LindenFlorian Daniel Zepf
Oct 9, 2018·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·W KönigschulteF D Zepf

❮ Previous
Next ❯

Related Concepts

Related Feeds

Attention Disorders

Attention is involved in all cognitive activities, and attention disorders are reported in patients with various neurological diseases. Here are the latest discoveries pertaining to attention disorders.