PMID: 6987493Jan 1, 1980Paper

Influence of recC and uvrD on ultraviolet-induced mutation to valine resistance in E. coli K12

Mutation Research
E Bardwell, P Howard-Flanders

Abstract

The production of mutants in E. coli exposed to ultraviolet light is initiated by photochemical reactions, and completed by metabolic processes controlled by recA and other genes. Ultraviolet-induced mutagenesis to valine resistance was measured in cells carrying recC, uvrD, or both recC and uvrD. The spontaneous and UV-induced mutagenesis was slightly greater in those carrying uvrD, as compared to recC or wild-type. At low doses, UV mutagenesis in the recC uvrD double mutant was greater than in either recC or wild-type, and was comparable to that in the uvrD strain, although this double mutant was very UV-sensitive and showed poor survival at doses above 2 J/m2.

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Citations

May 1, 1985·Mutation Research·I PietrzykowskaD Shugar

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