Influence of recombinant interferon alpha on nutritional status and growth pattern in children with chronic viral hepatitis

European Journal of Pediatrics
F GottrandJ P Farriaux

Abstract

Anorexia and weight loss are frequently reported as adverse effects during recombinant interferon alpha (rIFN-alpha) treatment. The aim of the present study was to assess both nutritional status and growth of children and adolescents treated with rIFN-alpha for chronic viral hepatitis. Eleven patients aged 4-16 years with histologically proven chronic active hepatitis (hepatitis B, n = 9; hepatitis C, n = 2) receiving rIFN-alpha subcutaneously thrice a week for 6 months were studied. Weight and height increments were assessed during the 6 months before starting rIFN-alpha. Weight and height were measured every 3 months (M0, M3, M6) during the 6 months of rIFN-alpha treatment, then every 6 months during the follow up period (6-36 months). Weight decreased in every child during rIFN-alpha treatment (weight loss varies from 0.5 to 2.6 kg after 3 months of treatment). Weight/age Z-score decreased from 0.12 at M0 to -0.69 at M3 (P < 0.01), then increased between M3 and M6 (-0.33) (P < 0.01), but normalized (0.02) only 6 months after completion of treatment. Nutritional status was significantly impaired during treatment (Z-score for weight/height decreased from 0.18 at M0 to -0.74 at M3, P < 0.01) and recovered progressively thereaft...Continue Reading

References

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Citations

Jan 8, 2004·Journal of Hepatology·Flavia Bortolotti
Dec 26, 2001·Journal of Pediatric Gastroenterology and Nutrition·Karen R JacobsonKathleen B Schwarz
Nov 29, 2007·Clinical Trials : Journal of the Society for Clinical Trials·Karen F MurrayUNKNOWN PEDS-C Clinical Research Network
Jul 10, 2010·Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association·Fazal A DanishSaeeda Yasmin
Jun 30, 2006·Pediatric Surgery International·Ingrid PlantinLars-Torsten Larsson
Feb 20, 2007·The Journal of Infection·Claudia TelescaLeonardo Baiocchi
Apr 2, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Doris B StraderUNKNOWN American Association for the Study of Liver Diseases
Jul 24, 2008·Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association·C Hamer
Mar 3, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Maureen M JonasChristopher Duggan
Apr 24, 2013·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Tomoyuki TsunodaTomoo Fujisawa
Oct 16, 2004·Clinics in Liver Disease·Annemarie Broderick, Maureen M Jonas
Sep 23, 2014·The Journal of Pediatrics·Maureen M JonasCharles Warne

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