Influence of renal failure on ciprofloxacin pharmacokinetics in rats.

Antimicrobial Agents and Chemotherapy
B Nouaille-DegorceR Farinotti

Abstract

Ciprofloxacin pharmacokinetics have been shown to be modified in patients with renal failure (e.g., the intestinal secretion of ciprofloxacin is increased). This study investigated the influence of renal failure on the pharmacokinetics of ciprofloxacin following oral and parenteral administration to rats of a dose of 50 mg/kg of body weight. After parenteral administration, only renal clearance (CLR) was reduced in nephrectomized rats (5.3+/-1.4 versus 17.8+/-4.7 ml/min/kg, P < 0.01, nephrectomized versus control rats). However, nonrenal clearance was increased in nephrectomized rats (32+/-4 versus 15+/-5 ml/min/kg, P < 0.01, nephrectomized versus control rats), suggesting compensatory mechanisms for reduced renal function. After oral administration, apparent total clearance and CLR were reduced (P < 0.01) in nephrectomized rats (117+/-25 and 6.8+/-4.4 ml/min/kg, respectively) compared with the values for control rats (185+/-9 and 22.6+/-5.3 ml/min/kg, respectively) and the area under the concentration-time curve was higher (P < 0.01) for nephrectomized rats (436.3+/-90.5 mg. min/liter) than for control rats (271.3+/-14.3 mg.min/liter). Terminal elimination half lives in the two groups remained constant after oral and parentera...Continue Reading

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Citations

Jul 31, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·C VeauB Lacour
Oct 21, 2011·Pharmaceutical Research·Ken-ichi Umehara, Gian Camenisch
Feb 2, 2012·Experimental Animals·Jong-Hwan LimHyo-In Yun
Nov 8, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Youn-Hwan HwangJin Yeul Ma
Jul 20, 1999·The Journal of Pharmacy and Pharmacology·K NaoraK Iwamoto
Feb 27, 1999·Antimicrobial Agents and Chemotherapy·S DautreyR Farinotti
Dec 12, 2003·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·K WaltonA G Renwick

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