PMID: 7862874Jan 1, 1994

Influence of repeated cocaine exposure on the endocrine and behavioral responses to stress in rats

Psychopharmacology
A D LevyL D Van de Kar

Abstract

Previous studies have determined that chronic cocaine exposure inhibits the serotonergic stimulation of hormone secretion. The present experiments were conducted to determine whether the endocrine responses to stress could be a useful approach to assess the influence of cocaine exposure on neuronal function. Male rats received twice daily injections of cocaine (1-15 mg/kg, IP) for 7 days. Animals were subsequently exposed to different stressors, i.e. conditioned emotional stress utilizing a low (0.5 mA) or high (1.5 mA) intensity footshock during training, or to immobilization stress. Immediately after the stress procedures, blood samples were collected for radioimmunoassay of plasma corticosterone, prolactin, and renin concentrations. Repeated cocaine exposure attenuated the stress-induced elevations of corticosterone and prolactin secretion, and attenuated some of the behavioral effects of the low intensity conditioned emotional stress. When exposed to the high intensity conditioned emotional stress, cocaine did not alter the endocrine or behavioral effects of stress. Finally, repeated cocaine exposure modified the immobilization stress-induced elevation of renin secretion; low doses of cocaine (1 or 5 mg/kg) attenuated, whil...Continue Reading

References

Oct 1, 1994·Journal of Affective Disorders·N A FinebergS A Montgomery
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Jul 20, 2002·Physiology & Behavior·Monika TrzcińskaRichard H Melloni
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Citations

Jan 1, 1977·Journal of Neuroscience Research·D Taylor, B T Ho
Oct 6, 1992·European Journal of Pharmacology·A D LevyL D Van de Kar
Mar 1, 1992·Pharmacology, Biochemistry, and Behavior·N A DarmaniR A Glennon
Mar 1, 1992·Pharmacology, Biochemistry, and Behavior·X M YangN E Goeders
Mar 3, 1992·European Journal of Pharmacology·A ImperatoS Puglisi-Allegra
Jul 1, 1991·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·M A HaanwinckelE De Castro e Silva
Jul 1, 1990·Pharmacology, Biochemistry, and Behavior·S J Yi, K M Johnson
Jan 1, 1991·Annual Review of Pharmacology and Toxicology·L D Van de Kar
Oct 1, 1990·Physiological Reviews·E HackenthalR Taugner
Mar 14, 1989·European Journal of Pharmacology·A SerranoB Scatton
Jan 14, 1986·European Journal of Pharmacology·J L D'EramoC Libertun
Jan 1, 1986·Neuroendocrinology·E L LienD Sullivan
Jan 1, 1988·Annals of the New York Academy of Sciences·S M AntelmanD J Edwards
Aug 9, 1988·Brain Research·D JacksonM J Zigmond
Jan 1, 1966·Acta Pharmacologica Et Toxicologica·S B Ross, A L Renyi
Sep 1, 1969·European Journal of Pharmacology·S B Ross, A L Renyi
Dec 1, 1967·European Journal of Pharmacology·S B Ross, A L Renyi

Related Concepts

Behavior, Animal
Ren
Preening
Mental Suffering
Hypokinesia, Experimental
Corticosterone
Cocaine Hydrochloride
Rats, Holtzman
Electroconvulsive Shock
Conditioning (Psychology)

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