Influence of repeated preexposure to arsenic on acetaminophen-induced oxidative stress in liver of male rats

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Ayyasamy ManimaranPalanisamy Sankar

Abstract

We evaluated whether repeated arsenic preexposure can increase acetaminophen-induced hepatic oxidative stress. Rats were exposed to arsenic (25 ppm; rat equivalent concentration of maximum groundwater contamination level) via drinking water for 28 days. Next day, they were given single oral administration of acetaminophen (420 or 1000 mg/kg b.w.). Hepatotoxicity was evaluated by assessing serum biomarkers, cytochrome-P450 (CYP) content, CYP3A4- and CYP2E1-dependent enzymes, lipid peroxidation and antioxidants. Arsenic or acetaminophen increased serum ALT and AST activities and depleted CYP. Arsenic decreased, but acetaminophen increased CYP-dependent enzyme activities. These agents independently increased lipid peroxidation and decreased antioxidants. Arsenic did not alter the effects of acetaminophen on serum biomarkers, caused further CYP depletion and decreased acetaminophen-mediated induction of drug-metabolizing enzymes. Arsenic enhanced the lower dose of acetaminophen-mediated lipid peroxidation and glutathione depletion with no further alterations in enzymatic antioxidants. However, arsenic attenuated the higher dose-mediated lipid peroxidation and glutathione depletion with improvement in glutathione peroxidase and glut...Continue Reading

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Citations

Nov 4, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Carol R GardnerDebra L Laskin
Jan 12, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Chhaya Rani MajhiSouvendra Nath Sarkar
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Dec 19, 2013·Environmental Toxicology·Palanisamy SankarSouvendra Nath Sarkar
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Jun 24, 2020·Journal of Hazardous Materials·Afsane BahramiAmirhossein Sahebkar
Aug 28, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yufen LaiLi Zou

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