Influence of resting heart rate on mortality in patients undergoing coronary angiography (from the Ludwigshafen Risk and Cardiovascular Health [LURIC] study)

The American Journal of Cardiology
Bríain ó HartaighWinfried März

Abstract

Several epidemiologic studies have reported an association between elevated heart rate (HR) at rest and reduced survival. The usefulness of HR at rest in predicting end points in high-risk patients is yet to be definitively established. The purpose of this study was to clarify the relation between HR at rest with total and cardiovascular mortality in patients who underwent coronary angiography. A total of 3,316 Caucasian patients with available coronary angiograms were prospectively followed from 2001 to 2011 (median 9.9 years). The effect of HR at rest on total and cardiovascular mortality was explored, while correcting for a number of confounders. Patients in the highest quartile (HR at rest ≥ 84 beats/min) had survival times reduced by 1.2 and 1.4 years for overall and cardiovascular mortality, respectively. Likewise, these patients had significantly elevated adjusted risk for total (hazard ratio 1.39, 95% confidence interval 1.17 to 1.67, p for trend <0.001) and cardiovascular mortality (hazard ratio 1.38, 95% confidence interval 1.08 to 1.78, p for trend = 0.004). In conclusion, HR at rest is an inexpensive, easily measured, and modifiable predictor of mortality.

References

Jun 1, 1987·American Heart Journal·W B KannelL A Cupples
Mar 22, 2001·Pharmacogenomics·B R WinkelmannUNKNOWN LURIC Study Group (LUdwigshafen RIsk and Cardiovascular Health)
Jun 29, 2005·Circulation·Peter Libby, Pierre Theroux
Sep 27, 2006·European Heart Journal·Stéphane CookOtto M Hess
Dec 11, 2007·International Journal of Cardiology·George D GiannoglouGeorge E Louridas
Oct 1, 2008·Nature Reviews. Immunology·Christian WeberPeter Libby
May 29, 2009·British Medical Bulletin·Jean-Claude Tardif
Jul 21, 2009·Progress in Cardiovascular Diseases·Christine Perret-GuillaumeAthanase Benetos
Jul 21, 2009·Progress in Cardiovascular Diseases·Francesco OrsoAldo Pietro Maggioni

❮ Previous
Next ❯

Citations

Sep 17, 2013·The American Journal of Cardiology·Andreas M PittarasPeter Kokkinos
Jun 30, 2012·International Journal of Cardiology·Christina ChrysohoouChristodoulos Stefanadis
Jun 24, 2014·American Heart Journal·Robert M CarneyAllan S Jaffe
Aug 21, 2016·The Journal of Clinical Hypertension·Michael A Weber, Daniel T Lackland
Jan 22, 2014·European Journal of Preventive Cardiology·Bríain Ó HartaighThomas M Gill
Feb 15, 2019·Scandinavian Journal of Clinical and Laboratory Investigation·Magnus T Jensen
Jul 25, 2013·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Shlomo Stern
Jan 1, 2017·Journal of the American Geriatrics Society·Kuibao LiLei Dong
Sep 5, 2020·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·Eva SteinbergerWinfried März
Oct 10, 2020·The Journal of Clinical Hypertension·Babak YazdaniBernhard K Krämer

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.