PMID: 15222722Jun 30, 2004Paper

Influence of rifampin on serum markers of cholesterol and bile acid synthesis in men

International Journal of Clinical Pharmacology and Therapeutics
D LütjohannC Reichel

Abstract

It has been demonstrated in preliminary studies that rifampin, a semisynthetic antibiotic and known inducer of hepatic cytochrome P450 3A4, reduces serum concentrations of total bile acids only in individuals with liver disease and elevated serum bile acid levels. We studied the effect of rifampin on concentrations of surrogate serum markers of cholesterol and bile acid synthesis as well as of cholesterol absorption in 10 male subjects before and after administration of rifampin (600 mg/day) for 6 days. Cholesterol and its precursors were analyzed by gas-liquid chromatography (GLC), bile acid intermediates and individual bile acids by isotope-dilution methods using GLC-mass spectrometry (MS) or by high-performance liquid chromatography (HPLC). Treatment with rifampin resulted in a 70% increase (p = 0.008) of the serum concentration of the bile acid precursor 7alpha-hydroxy-4-cholesten-3-one, which is a marker for bile acid production. Serum total cholesterol was not altered, however, treatment with rifampin elevated the ratio of lathosterol to cholesterol, an indicator of cholesterol synthesis, by 23% (p = 0.037). Interestingly, serum concentration of total bile acids decreased slightly by 29% (p = 0.022), mainly due to a lower...Continue Reading

Citations

May 2, 2012·Molecular and Cellular Endocrinology·Zsuzsanna S NagyLaszlo Nagy
Nov 26, 2009·Progress in Lipid Research·Stefano FiorucciAndrea Mencarelli
Jan 13, 2009·British Journal of Pharmacology·Gernot Zollner, Michael Trauner
Apr 8, 2016·Science Translational Medicine·Sebastian ZimmerEicke Latz
Aug 31, 2014·Journal of Lipid Research·Ylva BondeMats Rudling
Jan 6, 2018·Science·Ludovico Cantuti-CastelvetriMikael Simons
Feb 26, 2009·Nuclear Receptor Signaling·Changcheng ZhouBruce Blumberg
Mar 23, 2013·Molecular Pharmacology·Robert N HelsleyChangcheng Zhou
Mar 30, 2005·The Journal of Nutrition·Mark V BoekschotenMartijn B Katan
Nov 18, 2020·European Journal of Clinical Pharmacology·Dieter LütjohannBruno G Oertel
Mar 10, 2021·British Journal of Pharmacology·Mikko KarpaleJukka Hakkola
Aug 8, 2021·International Journal of Molecular Sciences·Grigorios ChristidisSenem Ceren Karatayli

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