Influence of sampling time and ultrafiltration coefficient of the dialysis membrane on cardiac troponin I and T.

Archives of Pathology & Laboratory Medicine
Giuseppe LippiGian Cesare Guidi

Abstract

The measurement of cardiac troponin I (TnI) and T (TnT) is essential to diagnose, guide therapy, and predict outcomes of the acute coronary syndrome. Increased levels of troponins, especially TnT, are frequently observed in patients on chronic hemodialysis (HD), reflecting ongoing and subclinical myocardial damage. Because these markers are increasingly used for stratification of cardiac risk in these patients, their behavior during HD should be acknowledged to optimize their clinical usefulness. TnI and TnT were measured in 34 patients pre-HD and post-HD by either high- or low-flux membranes. The post-HD concentrations were corrected for hemoconcentration. Pre-HD levels above the 99th percentile reference limits of the general population of TnI (>0.06 ng/ mL) and TnT (>0.01 ng/mL) were observed in 9% (13% high-flux, 6% low-flux membranes) and 88% (94% high-flux; 83% low-flux membranes) of the patients, respectively. No significant difference was observed in mean pre-HD values between patients dialyzed by low- and high-flux membranes. The overall decrease post-HD of both troponins (-21% and -17% for TnI and TnT, respectively) only reached statistical significance in patients dialyzed by low-flux membranes (-27% and -37% for TnI...Continue Reading

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Citations

Sep 29, 2017·Blood Purification·Diego CastiniMario Cozzolino
Dec 26, 2016·AIMS Genetics·Usman MahmoodMagid A Fahim
Dec 14, 2019·The American Journal of Emergency Medicine·Brit LongJonathan M Bronner
Jun 28, 2014·The International Journal of Artificial Organs·Muharrem IngecMehmet Horoz
Jul 6, 2021·Clinical Kidney Journal·Sunna SnaedalKarolina Szummer
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Jul 27, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Neeraj KumarJordan L Rosenstock

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