PMID: 8940754Sep 1, 1996Paper

Influence of selection bias on dose-time analysis: a theoretical investigation

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
J M Taylor, H R Withers

Abstract

We investigate the effect of patient selection factors on the interpretation of dose-time analyses of retrospective head and neck data treated with external beam radiation therapy. We use a computer simulation model to ascertain the influence of individualizing the fractionation regimen on the estimated steepness of dose-response and time-response estimates, on the probability of local control and on the validity of statistical tests and confidence intervals. We assume that the total dose and overall treatment time for each patient are altered by consideration of three possible factors, the pre treatment size of the tumor, the response of the tumor to therapy or the amount of acute effects. We find that individualizing treatment leads to very small improvements in the local control rate, but substantial biases in the estimates of the doubling time and the effective D0 value. Patient selection also compromises the validity of confidence intervals and tests. Despite this selection bias our results suggest that if there were no real effect of treatment time then the influence of individualizing treatments would not cause treatment time to be found to be as important as it has been shown to be in many studies. Assuming the fundamen...Continue Reading

References

Oct 1, 1992·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·H H Dubben
Dec 1, 1992·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J M Taylor, H R Withers
Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·H D ThamesW A Brock
Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·J F Fowler, M J Lindstrom
Mar 1, 1992·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·M B BartonE Maki
Nov 1, 1991·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·S M Bentzen, H D Thames
Jun 1, 1991·International Journal of Radiation Oncology, Biology, Physics·S M BentzenH D Thames
Nov 1, 1990·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·H D ThamesW Van den Bogaert
Nov 1, 1990·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J F FowlerC Lave
Apr 1, 1989·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J P BatainiC Lave
Aug 1, 1989·International Journal of Radiation Oncology, Biology, Physics·R J AmdurN J Cassisi
Jul 1, 1989·International Journal of Radiation Oncology, Biology, Physics·S L Tucker, H D Thames
Mar 1, 1989·International Journal of Radiation Oncology, Biology, Physics·B MaciejewskiA Hliniak
Jan 1, 1988·Acta Oncologica·H R WithersB Maciejewski
Apr 1, 1987·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·G K ZagarsL J Peters
Oct 15, 1995·International Journal of Radiation Oncology, Biology, Physics·H R WithersN Gupta
Sep 1, 1994·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·H H Dubben
Apr 1, 1994·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J H HendryA Agren-Cronqvist
Feb 1, 1994·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·K SkladowskiG G Steel
Feb 1, 1994·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·T J Keane
Feb 1, 1994·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·W L van PuttenP C Levendag
Jul 15, 1996·International Journal of Radiation Oncology, Biology, Physics·B M Dubray, H D Thames

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Citations

May 4, 1999·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·R SuwinskiH R Withers
Aug 1, 1997·International Journal of Radiation Oncology, Biology, Physics·J F Fowler
Apr 29, 1999·International Journal of Radiation Oncology, Biology, Physics·G SanguinetiV Vitale
Oct 16, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Stephan MadersbacherUrs E Studer

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